An activator of soluble guanylate cyclase
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BAY 41-2272

Item No. 10057

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine
CAS Number
256376-24-6
Molecular Formula
C20H17FN6
Formula Weight
360.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16.6 mg/mlDMF:PBS(pH 7.2)(1:6): 0.14 mg/mlDMSO: 12.5 mg/mlEthanol: 0.16 mg/ml
λmax
214, 255, 322 nm
SMILES
FC(C=CC=C1)=C1CN2N=C(C3=NC=C(C4CC4)C(N)=N3)C5=CC=CN=C52
InChi Code
InChI=1S/C20H17FN6/c21-16-6-2-1-4-13(16)11-27-20-14(5-3-9-23-20)17(26-27)19-24-10-15(12-7-8-12)18(22)25-19/h1-6,9-10,12H,7-8,11H2,(H2,22,24,25)
InChi Key
ATOAHNRJAXSBOR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $117

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    10 mg

    $218

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    25 mg

    $456

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    50 mg

    $853

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    Product Description

    BAY 41-2272 is a pyrazolopyridine compound that acts as an activator of sGC, stimulating activity to a level that would be expected to cause biologically important increases in cGMP at concentrations as low as 10-100 nM.1 Through this effect, it inhibits platelet aggregation (IC50 = 36 nM), induces relaxation of phenylephrine-preconstricted rabbit aorta rings (IC50 = 304 nM), and reduces proliferation in smooth muscle.1,2 BAY 41-2272 is effective in vivo, as it decreases mean arterial blood pressure in hypertensive rats.1 Unlike another sGC activator, YC-1 (Item No. 81560), BAY 41-2772 does not inhibit phosphodiesterases.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stasch, J.P., Becker, E.M., Alonso-Alija, C., et al. NO-independent regulatory site on soluble guanylate cyclase. Nature 410, 212-215 (2001).

    2. Evgenov, O.V., Pacher, P., Schmidt, P.M., et al. NO-independent stimulators and activators of soluble guanylate cyclase: Discovery and therapeutic potential. Nat. Rev. Drug Discov. 5(9), 755-768 (2006).

    3. Stasch, J.-P., Alonso-Alija, C., Apeler, H., et al. Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: In vitro studies. Br. J. Pharmacol. 135(2), 333-343 (2002).