A lipid soluble, esterified prodrug of AL 8810
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AL 8810 isopropyl ester

Item No. 10113

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5Z)-7-[(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-5-heptenoic acid, 1-methylethyl ester
CAS Number
208114-93-6
Molecular Formula
C27H37FO4
Formula Weight
444.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:1): 100 µg/ml
SMILES
CC(C)OC(CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@H](O)C2CC3=CC=CC=C3C2)[C@@H](F)C[C@@H]1O)=O
InChi Code
InChI=1S/C27H37FO4/c1-18(2)32-27(31)12-6-4-3-5-11-23-22(24(28)17-26(23)30)13-14-25(29)21-15-19-9-7-8-10-20(19)16-21/h3,5,7-10,13-14,18,21-26,29-30H,4,6,11-12,15-17H2,1-2H3/b5-3-,14-13+/t22-,23-,24+,25+,26+/m1/s1
InChi Key
NHXJEEIAJJWMNC-IHMKMYTQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $119

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    5 mg

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    10 mg

    $891

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    Product Description

    AL 8810 (Item No. 16735) is an 11β-fluoro analog of prostaglandin F2α (Item No. 16010) which acts as a potent and selective antagonist at the FP receptor.1 AL 8810 isopropyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost (Item No. 16812) and Travoprost.2,3 The pharmacology of AL 8810 isopropyl ester has not been published.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Griffen, B.W., Klimko, P., Crider, J.Y., et al. AL-8810: A novel prostaglandin F2α analog with selective antagonist effects at the prostaglandin F2α (FP) receptor. J. Pharmacol. Exp. Ther. 290(3), 1278-1284 (1999).

    2. Camras, C.B., Alm, A., Watson, P., et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Ophthalmology 103(11), 1916-1924 (1996).

    3. Sorbera, L.A., and Castañer, J. Travoprost. Drugs Future 25(1), 41-45 (2000).