For immunochemical detection of the CB1 receptor
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Applicable for Use with
301500CB1 Receptor Blocking Peptide
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CB1 Receptor Polyclonal Antibody

Item No. 101500

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Cannabinoid Receptor 1
  • CNR1
Immunogen
Synthetic peptide from the N-terminal extracellular region of human CB1 receptor
Formulation (Request formulation change)
500 µl of peptide affinity-purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
WB
Species Reactivity
(+) Human(+) Mouse(+) Rat
UniProt Accession №
P21554
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Product Description

    The CB1 receptor and the splice variant CB1a are localized mainly in the brain.1,2,3 The CB1 receptor is a G-protein coupled receptor that binds the active component of cannabis, Δ9-tetrahydrocannabinol. Human and rat CB1 receptors exhibit 97.3% homology at the amino acid level over the complete protein, and 100% homology within the peptide sequence used to make this antibody.4,1 This peptide exhibits no homology with the CB2 receptor. Based on the amino acid sequence, the CB1 receptor has a molecular weight of approximately 52,800.1 The CB1 receptor and the splice variant CB1a are localized mainly in the brain, whereas the CB2 receptor is localized predominantly in peripheral tissues, including the spleen and hemopoietic cells.4,1,2,3 Cayman’s CB1 Receptor Polyclonal Antibody can be used for Western blot applications. The antibody recognizes the N-terminal extracellular region of the CB1 receptor at 40 kDa from human samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matsuda, L.A., Lolait, S.J., Brownstein, M.J., et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346(6284), 561-564 (1990).

    2. Shire, D., Carillon, C., Kaghad, M., et al. An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. The Journal of Biological Chemisty 270(8), 3726-3731 (1995).

    3. Munro, S., Thomas, K.L., and Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365(6441), 61-65 (1993).

    4. Gérard, C.M., Mollereau, C., Vassart, G., et al. Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem. J. 279(Pt 1), 129-134 (1991).

    Product Citations

    Benz, A.H., Renne, C., Maronde, E., et al. Expression and functional relevance of cannabinoid receptor 1 in Hodgkin lymphoma. PLoS one 9(12), e81675 (2013).

    Bishay, P., Schmidt, H., Marian, C., et al. R-Flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids. PLoS One 5(5), e10628 (2010).