For immunochemical detection of the CB2 receptor
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CB2 Receptor Polyclonal Antibody

Item No. 101550

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Cannabinoid Receptor 2
  • CNR2
Immunogen
Synthetic peptide from the N-terminal region of human CB2 receptor
Formulation (Request formulation change)
500 µl of peptide-affinity purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
IHC and WB
Cross Reactivity
(+) CB2 receptor
Species Reactivity
(+) Human(+) Mouse
UniProt Accession №
P34972
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 ea (500 µl)

    $374

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    Product Description

    The CB2 receptor is localized predominantly in peripheral tissues, including the spleen and hemopoietic cells.1 The CB1 and CB2 receptors are G-protein coupled receptors that bind the active component of cannabis, Δ9-tetrahydrocannabinol, as well as anandamide which is an endogenous CB receptor ligand. This antibody has been raised against a sequence between the N-terminus and the first transmembrane domain of the protein of the human CB2 receptor.1 It can be used for western blotting and immunohistochemistry applications. Conserved amino acids between the CB1 and CB2 receptors in this region are minimal.2 Human and murine CB2 receptors exhibit 82% homology at the amino acid level over the complete protein.2 The CB2 receptor is localized predominantly in peripheral tissues, including the spleen and hemopoietic cells.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Munro, S., Thomas, K.L., and Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365(6441), 61-65 (1993).

    2. Shire, D., Calandra, B., Rinaldi-Carmona, M., et al. Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor. Biochim. Biophys. Acta 1307(2), 132-136 (1996).

    Product Citations

    Maccarone, R., Rapino, C., Zerti, D., et al. Modulation of type-1 and type-2 cannabinoid receptors by saffron in a rat model of retinal neurodegeneration. PLoS One 11(11), e0166827 (2016).

    Bouskila, J., Javadi, P., Casanova, C., et al. Rod photoreceptors express GPR55 in the adult vervet monkey retina. PLoS One 8(11), e81080 (2013).

    Bishay, P., Schmidt, H., Marian, C., et al. R-Flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids. PLoS One 5(5), e10628 (2010).