A stilbene with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

trans-trismethoxy Resveratrol

Item No. 10188

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dimethoxy-5-[(1E)-2-(4-methoxyphenyl)ethenyl]-benzene
CAS Number
22255-22-7
Synonyms
  • (E)-5-[2-(4-hydroxyphenyl)ethenyl]-1,3-benzene diol
  • TMS
  • trans-3,5,4'-trimethoxystilbene
Molecular Formula
C17H18O3
Formula Weight
270.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 10 mg/ml
λmax
218, 306, 319 nm
SMILES
COc1ccc(cc1)\C=C/c1cc(OC)cc(OC)c1
InChi Code
InChI=1S/C17H18O3/c1-18-15-8-6-13(7-9-15)4-5-14-10-16(19-2)12-17(11-14)20-3/h4-12H,1-3H3/b5-4+
InChi Key
GDHNBPHYVRHYCC-SNAWJCMRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $41

    Add

    100 mg

    $72

    Add

    250 mg

    $148

    Add

    500 mg

    $274

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    trans-trismethoxy Resveratrol is a polyketide synthase-derived stilbene originally isolated from Virola cuspidata that has diverse biological activities.1,2,3,4 It is cytotoxic to several cancer cell lines, including PC3, KB, HT-29, SW480, and HL-60 cells (IC50s =3.6, 10.2, 16.1, 54, and 2.5 µM, respectively).2 trans-trismethoxy Resveratrol (15 µM) inhibits TNF-α-induced activation of NF-κB in HEK293T cells in a reporter assay.3 It inhibits angiogenesis in zebrafish embryos when used at a concentration of 0.1 µM.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Austin, M.B., and Noel, J.P. The chalcone synthase superfamily of type III polyketide synthases. Nat. Prod. Rep. 20(1), 79-110 (2003).

    2. Aldawsari, F.S., and Velázquez-Martínez, C.A. 3,4',5-trans-Trimethoxystilbene; a natural analogue of resveratrol with enhanced anticancer potency. Invest. New Drugs 33(3), 775-786 (2015).

    3. Heynekamp, J.J., Weber, W.M., Hunsaker, L.A., et al. Subsitituted trans-stilbenes, including analogues of the natural product resveratrol, inhibit the human tumor necrosis factor alpha-induced activation of transcription factor nuclear factor kappaB. J. Med. Chem. 49(24), 7182-7189 (2006).

    4. Belleri, M., Ribatti, D., Nicoli, S., et al. Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4'-trimethoxystilbene. Mol. Pharmacol. 67(5), 1451-1459 (2005).