A potent, selective HDAC8 inhibitor
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PCI 34051

Item No. 10444

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide
CAS Number
950762-95-5
Molecular Formula
C17H16N2O3
Formula Weight
296.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 50 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 0.3 mg/ml
λmax
230, 285 nm
SMILES
ONC(C1=CC2=C(C=CN2CC3=CC=C(OC)C=C3)C=C1)=O
InChi Code
InChI=1S/C17H16N2O3/c1-22-15-6-2-12(3-7-15)11-19-9-8-13-4-5-14(10-16(13)19)17(20)18-21/h2-10,21H,11H2,1H3,(H,18,20)
InChi Key
AJRGHIGYPXNABY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    50 mg

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    100 mg

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    Cayman Chemical
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    Product Description

    PCI 34051 is a potent histone deacetylase (HDAC) 8 inhibitor (IC50 = 0.01 μM) with >200-fold selectivity over HDAC isoforms 1, 2, 3, 6, and 10 (IC50s = 4, >50, >50, 2.9, and 13 μM, respectively).1 PCI 34051 induces caspase-dependent apoptosis in cell lines derived from T-cell lymphomas or leukemias (GI50s = 2.4 - 4 μM), but not in other hematopoietic or solid tumor lines.1 This compound has also been used to support a critical role for HDAC8 in the coordinated deacetylation of the core cohesion component SMC3 during mitosis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Balasubramanian, S., Ramos, J., Luo, W., et al. A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. Leukemia 22(5), 1026-1034 (2008).

    2. Deardorff, M.A., Bando, M., Nakato, R., et al. HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle. Nature 489(7415), 313-317 (2012).