A CysLT2 receptor antagonist
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BayCysLT2

Item No. 10532

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[(3-carboxycyclohexyl)amino]carbonyl]-4-[3-[4-(4-phenoxybutoxy)phenyl]propoxy]-benzoic acid
CAS Number
712313-33-2
Synonyms
  • CAY10633
Molecular Formula
C34H39NO8
Formula Weight
589.7
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 20 mg/ml
λmax
220 nm
SMILES
O=C(NC1CCCC(C(O)=O)C1)C2=CC(C(O)=O)=CC=C2OCCCC(C=C3)=CC=C3OCCCCOC4=CC=CC=C4
InChi Code
InChI=1S/C34H39NO8/c36-32(35-27-10-6-9-25(22-27)33(37)38)30-23-26(34(39)40)15-18-31(30)43-21-7-8-24-13-16-29(17-14-24)42-20-5-4-19-41-28-11-2-1-3-12-28/h1-3,11-18,23,25,27H,4-10,19-22H2,(H,35,36)(H,37,38)(H,39,40)
InChi Key
GKPAULTWHHPIHX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $61

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    5 mg

    $260

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    10 mg

    $462

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    25 mg

    $1,006

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    Product Description

    BayCysLT2 is a cysteinyl leukotriene 2 (CysLT2) receptor antagonist (IC50 = 53 nM).1 It selectively inhibits calcium mobilization induced by leukotriene D4 (LTD4; Item No. 20310) in HEK293 cells expressing human CysLT2 receptors over HEK293 cells expressing CysLT1 receptors when used at a concentration of 100 nM. BayCysLT2 reverses LTC4-induced increases in coronary artery perfusion pressure and decreases in contractility in isolated perfused guinea pig hearts.2 In vivo, BayCysLT2 (3 mg/kg) reduces infarct volume in a human CysLT2 receptor transgenic mouse model of myocardial ischemia and reperfusion injury induced by left anterior descending coronary artery (LAD) ligation.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ni, N.C., Yan, D., Ballantyne, L.L., et al. A selective cysteinyl leukotriene receptor 2 antagonist blocks myocardial ischemia/reperfusion injury and vascular permeability in mice. J. Pharmacol. Exp. Ther. 339(3), 768-778 (2011).

    2. Harter, M., Erguden, J., Wunder, F., et al. Isophtalic acid derivatives. US20060154912A1, (2006).