HDAC inhibitor
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Scriptaid

Item No. 10572

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexananmide
CAS Number
287383-59-9
Synonyms
  • GCK 1026
Molecular Formula
C18H18N2O4
Formula Weight
326.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 2.5 mg/ml
λmax
234, 333 nm
SMILES
O=C(C1=CC=CC2=C1C3=CC=C2)N(CCCCCC(NO)=O)C3=O
InChi Code
InChI=1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
InChi Key
JTDYUFSDZATMKU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $40

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    5 mg

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    10 mg

    $152

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    Cayman Chemical
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    Product Description

    Scriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems.1 It induces cell cycle arrest in colon cancer cells in culture and inhibits tumor growth in vitro and in vivo.2,3 Scriptaid also facilitates the cloning of inbred mouse strains produced by somatic cell nuclear transfer.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Su, G.H., Sohn, T.A., Ryu, B., et al. A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. Cancer Res. 60(12), 3137-3142 (2000).

    2. Keen, J.C., Yan, L., Mack, K.M., et al. A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor α (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine. Breast Cancer Res. Treat. 81(3), 177-186 (2003).

    3. Lee, E.J., Lee, B.B., Kim, S.J., et al. Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. Int. J. Oncol. 33(4), 767-776 (2008).

    4. Van Thuan, N., Bui, H.T., Kim, J.H., et al. The histone deacetylase inhibitor scriptaid enhances nascent mRNA production and rescues full-term development in cloned inbred mice. Reproduction 138(2), 309-317 (2009).

    Product Citations

    Soriano-Castell, D., Currais, A., and Maher, P. Defining a pharmacological inhibitor fingerprint for oxytosis/ferroptosis. Free Radic. Biol. Med. S0891-5849(21), (2021).