Agonist of GPR119
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AS-1269574

Item No. 10626

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[2-(4-bromophenyl)-6-methyl-4-pyrimidinyl]amino]-ethanol
CAS Number
330981-72-1
Molecular Formula
C13H14BrN3O
Formula Weight
308.2
Purity
≥98%
Formulation
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7) (1:10): 0.1 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
λmax
253 nm
SMILES
BrC(C=C1)=CC=C1C2=NC(NCCO)=CC(C)=N2
InChi Code
InChI=1S/C13H14BrN3O/c1-9-8-12(15-6-7-18)17-13(16-9)10-2-4-11(14)5-3-10/h2-5,8,18H,6-7H2,1H3,(H,15,16,17)
InChi Key
DUKPGOOUJNUIOI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $129

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    25 mg

    $283

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    GPR119, a glucose-dependent insulinotropic receptor, is a Gs protein-coupled receptor that is expressed in pancreas β-cells and intestinal L-cells.1 Activation of GPR119 by the endogenous ligands lyso-phosphatidylcholine and oleoyl ethanolamide increases intracellular cAMP levels and promotes glucose-stimulated insulin secretion.1,2 AS-1269574 is an agonist of GPR119 that is effective both in isolated cells and in vivo.3 It increases cAMP levels in HEK293 cells transfected with human GPR119 (EC50 = 2.5 μM) and glucose-stimulated insulin secretion in mice (100 mg/kg).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Overton, H.A., Babbs, A.J., Doel, S.M., et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 3(3), 167-175 (2006).

    2. Soga, T., Ohishi, T., Matsui, T., et al. Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor. Biochem. Biophys. Res. Commun. 326(4), 744-751 (2005).

    3. Yoshida, S., Ohishi, T., Matsui, T., et al. Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. Biochem. Biophys. Res. Commun. 400(3), 437-441 (2010).