Pure human recombinant protein
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EED (human recombinant)

Item No. 10628

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Embryonic Ectoderm Development
Purity
≥95% estimated by SDS-PAGE
Source
Recombinant N-terminal His-tagged protein, expressed in Sf21 cells using a baculovirus expression system
Amino Acids
1-441 (full-length)
MW
53.5 kDa
UniProt Accession №
O75530
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    50 µg

    $389

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    Product Description

    The human-Embryonic ectoderm development (EED) protein is a WD40 repeat-containing protein that forms part of the Polycomb repressive complex 2 (PRC2).1,2 The PRC2 core complex contains the catalytic subunit EZH2 (Enhancer of zeste 2), SUZ12 (Suppressor of zeste) and EED. The EED subunit does not contain methyltransferase activity. However, transcriptional repression by PRC2-mediated trimethylation of lysine 27 on Histone H3 (H3K27me3) has been shown to be dependent on EED binding to repressive histone marks.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schumacher, A., Lichtarge, O., Schwartz, S., et al. The murine polycomb-group gene EED and its human orthologue: Functional implications of evolutionary conservation. Genomics 54, 79-88 (1998).

    2. Suganuma, T., and Workman, J.L. WD40 repeats arrange histone tails for spreading of silencing. J. Mol. Cell Biol. 2(2), 81-83 (2010).

    3. Margueron, R., Justin, N., Ohno, K., et al. Role of the polycomb protein EED in the propagation of repressive histone marks. Nature 461, 762-767 (2009).