An inhibitor of JAK2/STAT3 signaling
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FLLL32

Item No. 10638

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E,2'E)-1,1'-cyclohexylidenebis[3-(3,4-dimethoxyphenyl)]-2-propen-1-one
CAS Number
1226895-15-3
Synonyms
  • JAK2 Inhibitor X
Molecular Formula
C28H32O6
Formula Weight
464.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 15 mg/mlEthanol: Slightly Soluble
λmax
355 nm
SMILES
O=C(/C=C/C1=CC(OC)=C(OC)C=C1)C2(C(/C=C/C3=CC=C(OC)C(OC)=C3)=O)CCCCC2
InChi Code
InChI=1S/C28H32O6/c1-31-22-12-8-20(18-24(22)33-3)10-14-26(29)28(16-6-5-7-17-28)27(30)15-11-21-9-13-23(32-2)25(19-21)34-4/h8-15,18-19H,5-7,16-17H2,1-4H3/b14-10+,15-11+
InChi Key
NQDROBVIYYEMDQ-WFYKWJGLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $43

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    5 mg

    $106

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    10 mg

    $148

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    25 mg

    $260

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    Product Description

    FLLL32 is a cell-permeable analog of curcumin (Item No. 81025) that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50 = ~5 µM).1,2 It blocks signaling from IFN-α or IL-6 through JAK2/STAT3 and induces apoptosis in several types of cancer cells.1,2 FLLL32 does not interfere with IFN-γ-induced STAT1 signaling and does not adversely affect the function or viability of immune cells.1 Through its effects on JAK2/STAT3 signaling, FLLL32 enhances the chemo- and radiosensitivity of cancer cells.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bill, M.A., Fuchs, J.R., Li, C., et al. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity. Mol. Cancer 9(165), (2010).

    2. Lin, L., Hutzen, B., Zuo, M., et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res. 70(6), 2445-2454 (2010).

    3. Abuzeid, W.M., Davis, S., Tang, A., et al. Sensitization of head and neck cancer to cisplatin through the use of a novel curcumin analog. Arch. Otolaryngol. Head Neck Surg. 137(5), 499-507 (2011).

    4. Wu, X., Tang, W., Marquez, R.T., et al. Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling. Oncotarget 7(10), 11708-11723 (2016).