An Analytical Reference Standard
Features
  • This product has been formulated as an exempt preparation which meets criteria established by the US DEA
  • Possession of a DEA Controlled Substance registration is not necessary nor is a DEA 222 form required to purchase this product
  • This product is intended to be used as an analytical reference standard
  • Bulk material is available for academic research at qualified institutions; please contact our sales department for pricing
Related Products
Alternative(s)
10903JWH 200-d5
Unlabeled Version(s)
10902JWH 200 13171JWH 200 (exempt preparation)
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JWH 200-d5 (exempt preparation)

Item No. 10682

Exempt Product (US)
Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl-2',4',5',6',7'-d5]-1-naphthalenyl-methanone
CAS Number
1651833-51-0
Molecular Formula
C25H19D5N2O2
Formula Weight
389.5
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solution in acetonitrile
Solubility(Learn about Variance in Solubility)
Acetonitrile: 14 mg/mlDMF: 25 mg/mlDMF:PBS(pH 7.2)(1:6): 0.1 mg/mlDMSO: 20 mg/mlMethanol: 2 mg/mlMethyl Acetate: 5 mg/ml
λmax
219, 247, 314 nm
SMILES
O=C(C1=CC=CC2=C1C=CC=C2)C3=C([2H])N(CCN4CCOCC4)C5=C([2H])C([2H])=C([2H])C([2H])=C53
InChi Code
InChI=1S/C25H24N2O2/c28-25(22-10-5-7-19-6-1-2-8-20(19)22)23-18-27(24-11-4-3-9-21(23)24)13-12-26-14-16-29-17-15-26/h1-11,18H,12-17H2/i3D,4D,9D,11D,18D
InChi Key
SZWYXJHTNGJPKU-JXQMETBUSA-N
Regulatory Information
DEA Exempt Notification
This product is a DEA exempt preparation of a scheduled compound - does not require DEA Controlled Substance registration or DEA 222 form. For alternate sizes please contact sales.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $168

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    Product Description

    JWH 200-d5 (exempt preparation) contains five deuterium atoms at the 2', 4' ,5', 6', and 7' positions. It is intended for use as an internal standard for the quantification of JWH 200 (exempt preparation) (Item No. 13171) by GC- or LC-MS. JWH 200 is an aminoalkylindole that acts as a cannabinoid (CB) receptor ligand. It binds to the CB1 receptor with high-affinity (IC50 = 7.8-42 nM).1,2 The effects of JWH 200 in locomotor activity, tail-flick latency, hypothermia, and ring-immobility tests are comparable or superior to Δ9-THC or WIN 55,212.3 It potently inhibits the contraction of electrically-stimulated murine vas deferens (IC50 = 3.7-6.0 nM).4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eissenstat, M.A., Bell, M.R., D'Ambra, T.E., et al. Aminoalkylindoles: Structure-activity relationships of novel cannabinoid mimetics. J. Med. Chem. 38(16), 3094-3105 (1995).

    2. Huffman, J.W., Mabon, R., Wu, M.J., et al. 3-indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor. Bioorgan. Med. Chem. 11(4), 539-549 (2003).

    3. Compton, D.R., Gold, L.H., Ward, S.J., et al. Aminoalkylindole analogs: Cannabimimetic activity of a class of compounds structurally distinct from Δ9-tetrahydrocannabinol. J. Pharmacol. Exp. Ther. 263(3), 1118-1126 (1992).

    4. Pacheco, M., Childers, S.R., Arnold, R., et al. Aminoalkylindoles: Actions on specific G-protein-linked receptors. J. Pharmacol. Exp. Ther. 257(1), 170-183 (1991).

    5. Bell, M.R., D'Ambra, T.E., Kumar, V., et al. Antinociceptive (aminoalkyl) indoles. J. Med. Chem. 34(3), 1099-1110 (1991).