TIP60 (human, recombinant)

TIP60 is a member of the MYST family of lysine acetyl transferases. It has been shown to acetylate histones, p53, and the Ataxia Telangiectasia Mutant (ATM) protein kinase.¹ As a component of the TIP60-p400 complex, TIP60 acetylates transcription repressors in order to inhibit gene transcription.² In complexes without p400, TIP60 is part of a chromatin remodeling complex which plays an important role in double-stranded DNA break repair. Acetylation of histone γH2AX allows formation of the γH2AX repair foci, and acetylation of ATM is one of the early steps in double-stranded DNA break repair. Furthermore, TIP60 is bound by the cytoplasmic tail of β-amyloid precursor protein which drives gene transcription, apoptosis, and potentially a role in Alzheimer’s disease pathogenesis.³

WARNING This product is not for human or veterinary use.

1. Sun, Y., Jiang, X., and Price, B.D. Tip60: Connecting chromatin to DNA damage signaling. Cell Cycle 9(5), 930-936 (2010).

2. Fazzio, T.G., Hurr, J.T., and Panning, B. Chromatin regulation Tip(60)s the balance in embryonic stem cell self-renewal. Cell Cycle 7(21), 3302-3306 (2008).

3. Wu, J., Wang, J., Li, M., et al. Small molecule inhibitors of histone acetyltransferase Tip60. Bioorg. Chem. 39(1), 53-58 (2011).