For immunochemical detection of ANGPTL3
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ANGPTL3 (human) Monoclonal Antibody (Clone Kairos-37)

Item No. 10805

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Angiopoietin-5
  • Angiopoietin-like 3
  • Angiopoietin-related Protein 3
  • ANG-5
Immunogen
Recombinant human ANGPTL3
Clone Designation
Kairos-37
Formulation (Request formulation change)
A 1 mg/ml solution in PBS, pH 7.4
Host
Mouse
Isotype
IgG1κ
Applications
ELISA, WB
Cross Reactivity
(-) Human ANGPTL1(-) Human ANGPTL2(-) Human ANGPTL4(-) Human ANGPTL6(-) Human ANGPTL7
Species Reactivity
(+) Human ANGPTL3
Origin
Animal/Mouse
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 µg

    $290

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    100 µg

    $355

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

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    Product Description

    Angiopoietin-like 3 (ANGPTL3) is an angiopoietin-related protein involved in lipid metabolism.1,2 It is composed of a signal peptide, coiled-coil domain, linker region, and C-terminal fibrinogen-like domain.2,3 ANGPTL3 is expressed in adult liver and during embryonic development.3 It inhibits the activity of lipoprotein lipase and endothelial lipase, which increases plasma triglycerides and HDL-cholesterol (HDL-C) levels.4,5,6 Loss-of-function mutations in ANGPTL3 are associated with decreased risk of coronary artery disease, coronary atherosclerosis, or myocardial infarction.6 Formulations containing monoclonal antibodies targeting ANGPTL3 have been used in the treatment of homozygous familial hypercholesterolemia. Cayman’s ANGPTL3 (human) Monoclonal Antibody (Clone Kairos-37) can be used for ELISA and Western blot (WB) applications. The antibody recognizes ANGPTL3 at approximately 68 kDa and a cleaved band of approximately 35 kDa from human samples.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kadomatsu, T., Tabata, M., and Oike, Y. Angiopoietin-like proteins: Emerging targets for treatment of obesity and related metabolic diseases. FEBS J. 278(4), 559-564 (2011).

    2. Oike, Y., Akao, M., Kubota, Y., et al. Angiopoietin-like proteins: Potential new targets for metabolic syndrome therapy. Trends Mol. Med. 11(10), 473-479 (2005).

    3. Conklin, D., Gilbertson, D., Taft, D.W., et al. Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics 62(3), 477-482 (1999).

    4. Shan, L., Yu, X.C., Liu, Z., et al. The Angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanisms. The Journal of Biological Chemisty 284(3), 1419-1424 (2009).

    5. Shimamura, M., Matsuda, M., Yasumo, H., et al. Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. Arterioscler. Thromb. Vasc. Biol. 27(2), 366-372 (2007).

    6. Luo, F., Das, A., Khetarpal, S.A., et al. ANGPTL3 inhibition, dyslipidemia, and cardiovascular diseases. Trends Cardiovasc. Med. 34(4), 215-222 (2024).