A 5-LO inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Cinnamyl-3,4-dihydroxy-α-Cyanocinnamate

Item No. 10858

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid, 3-phenyl-2-propen-1-yl ester
CAS Number
132465-11-3
Synonyms
  • CDC
Molecular Formula
C19H15NO4
Formula Weight
321.3
Purity
≥97%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/mlEthanol: 0.25 mg/ml
λmax
251, 376 nm
SMILES
O=C(/C(C#N)=C/C1=CC=C(O)C(O)=C1)OC/C=C/C2=CC=CC=C2
InChi Code
InChI=1S/C19H15NO4/c20-13-16(11-15-8-9-17(21)18(22)12-15)19(23)24-10-4-7-14-5-2-1-3-6-14/h1-9,11-12,21-22H,10H2/b7-4+,16-11+
InChi Key
XGHYFEJMJXGPGN-UYHGDYIZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $39

    Add

    10 mg

    $74

    Add

    50 mg

    $306

    Add

    100 mg

    $497

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is an inhibitor of 5-lipoxygenase (5-LO; IC50 = 15 nM).1 It is selective for 5-LO over 12-LO and 15-LO (IC50s = 500 and 300 nM, respectively). CDC inhibits 5-LO product formation induced by the calcium ionophore A23187 (Item No. 11016) in isolated human polymorphonuclear leukocytes (PMNs), monocytes, and whole blood (IC50s = 0.5, 0.45, and 1.5 µM, respectively). In vivo, CDC (3.5 mg/kg) increases survival in a mouse model of lethal shock induced by platelet-activating factor (PAF). It also reduces pleural levels of leukotriene B4 (LTB4; Item No. 20110) in a rat model of carrageenan-induced pleurisy.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pergola, C., Jazzar, B., Rossi, A., et al. Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent inhibitor of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 338(1), 205-213 (2011).