A 5-LO inhibitor
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Cinnamyl-3,4-dihydroxy-α-Cyanocinnamate

Item No. 10858

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-2-cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid, 3-phenyl-2-propen-1-yl ester
CAS Number
132465-11-3
Synonyms
  • CDC
Molecular Formula
C19H15NO4
Formula Weight
321.3
Purity
≥97%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/mlEthanol: 0.25 mg/ml
λmax
251, 376 nm
SMILES
O=C(/C(C#N)=C/C1=CC=C(O)C(O)=C1)OC/C=C/C2=CC=CC=C2
InChi Code
InChI=1S/C19H15NO4/c20-13-16(11-15-8-9-17(21)18(22)12-15)19(23)24-10-4-7-14-5-2-1-3-6-14/h1-9,11-12,21-22H,10H2/b7-4+,16-11+
InChi Key
XGHYFEJMJXGPGN-UYHGDYIZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    50 mg

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    100 mg

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    Product Description

    Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is an inhibitor of 5-lipoxygenase (5-LO; IC50 = 15 nM).1 It is selective for 5-LO over 12-LO and 15-LO (IC50s = 500 and 300 nM, respectively). CDC inhibits 5-LO product formation induced by the calcium ionophore A23187 (Item No. 11016) in isolated human polymorphonuclear leukocytes (PMNs), monocytes, and whole blood (IC50s = 0.5, 0.45, and 1.5 µM, respectively). In vivo, CDC (3.5 mg/kg) increases survival in a mouse model of lethal shock induced by platelet-activating factor (PAF). It also reduces pleural levels of leukotriene B4 (LTB4; Item No. 20110) in a rat model of carrageenan-induced pleurisy.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pergola, C., Jazzar, B., Rossi, A., et al. Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC) is a potent inhibitor of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 338(1), 205-213 (2011).