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Clofibrate

Item № 10956
CAS № 637-07-0
Purity ≥98%
product image
                (CAS 637-07-0)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     500 mg $13.00 0.00
     1 g $25.00 0.00
     5 g $104.00 0.00
     10 g $182.00 0.00

Pricing updated 2019-07-17. Prices are subject to change without notice.

Description
Synonyms
  • ICI 28257
  • NSC 79389

Clofibrate is a selective agonist of peroxisome proliferator-activated receptor α (PPARα).1 In a transactivation assay, clofibrate exhibits EC50 values of 50 and 55 µM for murine and human PPARα, respectively. It also binds to PPARγ but with 10-fold less affinity and is inactive at PPARδ at concentrations up to 100 µM. Formulations containing clofibrate have been used to treat dyslipidemia and cardiovascular disease.

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Technical Information
Formal Name
2-(4-chlorophenoxy)-2-methyl-propanoic acid, ethyl ester
CAS Number
637-07-0
Synonyms
  • ICI 28257
  • NSC 79389
Molecular Formula
C12H15ClO3
Formula Weight
242.7
Purity
≥98%
Formulation
A neat oil
λmax
226, 280 nm
SMILES
ClC1=CC=C(OC(C)(C)C(OCC)=O)C=C1
InChI Code
InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
InChI Key
KNHUKKLJHYUCFP-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 1 year
Downloads & Resources
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery J. Med. Chem. 43(4), 528-550 (2000).

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