A selective PPARα agonist
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Active Metabolite(s)
21608Clofibric Acid
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Clofibrate

Item No. 10956

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-chlorophenoxy)-2-methyl-propanoic acid, ethyl ester
CAS Number
637-07-0
Synonyms
  • ICI 28257
  • NSC 79389
Molecular Formula
C12H15ClO3
Formula Weight
242.7
Purity
≥98%
Formulation
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 80 mg/mlEthanol: 80 mg/mlEthanol:PBS(pH 7.2) (1:5): .1 mg/ml
λmax
226, 280 nm
SMILES
ClC1=CC=C(OC(C)(C)C(OCC)=O)C=C1
InChi Code
InChI=1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
InChi Key
KNHUKKLJHYUCFP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $20

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    1 g

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    5 g

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    10 g

    $246

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Clofibrate is a selective agonist of peroxisome proliferator-activated receptor α (PPARα).1 In a transactivation assay, clofibrate exhibits EC50 values of 50 and 55 µM for murine and human PPARα, respectively. It also binds to PPARγ but with 10-fold less affinity and is inactive at PPARδ at concentrations up to 100 µM. Formulations containing clofibrate have been used to treat dyslipidemia and cardiovascular disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Willson, T.M., Brown, P.J., Sternbach, D.D., et al. The PPARs: From orphan receptors to drug discovery. J. Med. Chem. 43(4), 527-550 (2000).