A synthetic glucocorticoid
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Dexamethasone

Item No. 11015

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-fluoro-11β,17,21-trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione
CAS Number
50-02-2
Synonyms
  • MK-125
  • NSC 34521
Molecular Formula
C22H29FO5
Formula Weight
392.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/mlEthanol: 3 mg/ml
SMILES
O=C1C=C[C@]2(C(CC[C@]3([H])[C@@]2([C@H](C[C@]4([C@]3(C[C@H]([C@]4(O)C(CO)=O)C)[H])C)O)F)=C1)C
InChi Code
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChi Key
UREBDLICKHMUKA-CXSFZGCWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $65

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    1 g

    $98

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    5 g

    $423

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    Product Description

    Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively).1 Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.2 This product is also available as part of Cayman's Hepatocyte Differentiation Reagent Kit (Item No. 44737).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mulatero, P., Panarelli, M., Schiavone, D., et al. Impaired cortisol binding to glucocorticoid receptors in hypertensive patients. Hypertension 30(5), 1274-1278 (1997).

    2. Beck, I.M., Vanden Berghe, W., Vermeulen, L., et al. Crosstalk in inflammation: The interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr. Rev. 30(7), 830-882 (2009).

    Product Citations

    Tan, D., Konduri, S., Ertunc, M.E., et al. A class of anti-inflammatory lipids decrease with aging in the central nervous system. Nat. Chem. Biol. 19(2), 187-197 (2023).

    Cho, Y.K., Yoon, Y.C., Im, H., et al. Adipocyte lysoplasmalogenase TMEM86A regulates plasmalogen homeostasis and protein kinase A-dependent energy metabolism. Nat. Commun. 13(1), 4084 (2022).