An internal standard for the quantification of dexamethasone
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Unlabeled Version(s)
11015Dexamethasone
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Dexamethasone-d4

Item No. 22100

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-fluoro-11β,17,21-trihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione-4,6,21,21-d4
CAS Number
2483831-63-4
Molecular Formula
C22H25D4FO5
Formula Weight
396.5
Purity
≥99% deuterated forms (d1-d4)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 30 mg/mlEthanol: 3 mg/ml
SMILES
O=C1C=C[C@@]2(C)C(C([2H])C[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(C([2H])([2H])O)=O)=C1[2H]
InChi Code
InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1/i4D,9D,11D2/t4?,12-,15+,16+,17+,19+,20+,21+,22+
InChi Key
UREBDLICKHMUKA-SOEBWSEYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $75

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    1 mg

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    5 mg

    $479

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    10 mg

    $882

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    Product Description

    Dexamethasone-d4 is intended for use as an internal standard for the quantification of dexamethasone (Item No. 11015) by GC- or LC-MS. Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively).1 Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mulatero, P., Panarelli, M., Schiavone, D., et al. Impaired cortisol binding to glucocorticoid receptors in hypertensive patients. Hypertension 30(5), 1274-1278 (1997).

    2. Beck, I.M., Vanden Berghe, W., Vermeulen, L., et al. Crosstalk in inflammation: The interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr. Rev. 30(7), 830-882 (2009).