A cytotoxic macrolide
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Kendomycin

Item No. 11037

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(13E)-6R,7S,8R,9R,10,11,12S,15,16S,17,18S,19S-dodecahydro-4,7,19-trihydroxy-2,6,8,12,14,16,18-heptamethyl-1,19:5R,9-diepoxybenzocyclooctadecen-3(5H)-one
CAS Number
183202-73-5
Synonyms
  • TAN 2162
Molecular Formula
C29H42O6
Formula Weight
486.6
Purity
≥90%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleMethanol: soluble
SMILES
C[C@@H](CC[C@]1([H])[C@H](C)[C@H](O)[C@@H](C)[C@](O1)([H])C2=C(O)C3=O)/C=C(C[C@@H](C)C[C@H](C)[C@@]4(O)C=C2C(O4)=C3C)\C
InChi Code
InChI=1S/C29H42O6/c1-14-8-9-22-18(5)24(30)19(6)28(34-22)23-21-13-29(33,17(4)12-16(3)11-15(2)10-14)35-27(21)20(7)25(31)26(23)32/h10,13-14,16-19,22,24,28,30,32-33H,8-9,11-12H2,1-7H3/b15-10+/t14-,16+,17-,18-,19+,22+,24-,28+,29+/m0/s1
InChi Key
HKLDUJXJTQJSEJ-OLXNOMCWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

    $90

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    500 µg

    $241

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    Cayman Chemical
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    Product Description

    Kendomycin is a macrolide from Streptomyces which displays potent cytotoxicity against several carcinoma cell lines (GI50 < 100 nM).1 It also acts as an endothelin receptor antagonist and has antiosteoporotic activities.1 Certain effects are thought to be mediated through inhibition of proteasomal degradation of proteins.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bahnck, K.B., and Rychnovsky, S.D. Formal synthesis of (–)-kendomycin featuring a Prins-cyclization to construct the macrocycle. J. Am. Chem. Soc. 130(39), 13177-13181 (2008).