A selective NOD1 inhibitor
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Nodinitib-1

Item No. 11040

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(4-methylphenyl)sulfonyl]-1H-benzimidazol-2-amine
CAS Number
799264-47-4
Synonyms
  • CID-1088438
  • ML-130
Molecular Formula
C14H13N3O2S
Formula Weight
287.3
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:8): 0.11 mg/mlDMSO: 13 mg/ml
λmax
243 nm
SMILES
NC1=NC2=CC=CC=C2N1S(=O)(C3=CC=C(C)C=C3)=O
InChi Code
InChI=1S/C14H13N3O2S/c1-10-6-8-11(9-7-10)20(18,19)17-13-5-3-2-4-12(13)16-14(17)15/h2-9H,1H3,(H2,15,16)
InChi Key
SRFABRWQVPCPRG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $49

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    10 mg

    $93

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    25 mg

    $213

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    50 mg

    $376

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    Product Description

    Noditinib-1 selectively inhibits NOD1-dependent activation of NF-κB and MAPK signaling (IC50 = 0.6 μM) and also inhibits NOD1-induced IL-8 production in MCF-7 cells without affecting viability.1 In ex vivo dendritic cell culture, 15 μM noditinib-1 reduced cell-surface expression of CD83, CD86, and HLA-DR and inhibited expression of IL-1β, IL-6, and TNF-α. The mechanism of this inhibitor’s activity is thought to involve alteration of the subcellular targeting of NOD1.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Correa, R.G., Khan, P.M., Askari, N., et al. Discovery and characterization of 2-aminobenximidazole derivatives as selective NOD1 inhibitors. Chem. Biol. 18(7), 825-832 (2011).