A phenol with diverse biological activities
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4'-O-Methylhonokiol

Item No. 11089

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4′-methoxy-3′,5-di-2-propen-1-yl-[1,1′-biphenyl]-2-ol
CAS Number
68592-15-4
Synonyms
  • NSC 293101
  • 4-Methoxyhonokiol
Molecular Formula
C19H20O2
Formula Weight
280.4
Purity
≥95%
Formulation (Request formulation change)
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 33 mg/mlEthanol: 33 mg/mlEthanol:PBS (pH 7.2) (1:2): 0.3 mg/ml
SMILES
C=CCC1=CC(C2=CC(CC=C)=C(OC)C=C2)=C(O)C=C1
InChi Code
InChI=1S/C19H20O2/c1-4-6-14-8-10-18(20)17(12-14)15-9-11-19(21-3)16(13-15)7-5-2/h4-5,8-13,20H,1-2,6-7H2,3H3
InChi Key
OQFHJKZVOALSPV-UHFFFAOYSA-N
Origin
Plant/Magnolia officinalis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $42

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    1 mg

    $79

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    5 mg

    $183

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    10 mg

    $322

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    4'-O-Methylhonokiol is a phenol that has been found in M. grandiflora and has diverse biological activities.1,2,3,4 It is active against the bacteria B. subtilis, S. aureus, and M. smegmatis (MIC = 2.5 µg/ml for all) and the fungus T. mentagrophytes (MIC = 1.25 µg/ml).1 4'-O-Methylhonokiol (10 and 30 µM) inhibits LPS-induced activation of NF-kB and production of nitric oxide (NO) in RAW 264.7 macrophages.2 In vivo, 4'-O-Methylhonokiol (20 and 200 mg/kg) reduces carrageenan-induced paw edema in mice. It reduces neuronal apoptosis and escape latency in the Morris water maze in a mouse model of Alzheimer's disease induced by amyloid-β 1-42 (Aβ42) when administered at a dose of 1 mg/kg.3 4-O-methylhonokiol also reduces plasma cholesterol and triglyceride levels, ameliorates hepatic steatosis, and improves insulin resistance in a mouse model of high-fat diet-induced obesity.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Clark, A.M., El-Feraly, F.S., and Li, W.S. Antimicrobial activity of phenolic constituents of Magnolia grandiflora L. J. Pharm. Sci. 70(8), 951-952 (1981).

    2. Zhou, H.Y., Shin, E.M., Guo, L.Y., et al. Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-kappaB, JNK and p38 MAPK inactivation. Eur. J. Pharmacol. 586(1-3), 340-349 (2008).

    3. Lee, J.W., Lee, Y.K., Lee, B.J., et al. Inhibitory effect of ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on memory impairment and neuronal toxicity induced by beta-amyloid. Pharmacol. Biochem. Behav. 95(1), 31-40 (2010).

    4. Zhang, Z., Chen, J., Jiang, X., et al. The Magnolia bioactive constituent 4-O-methylhonokiol protects against high-fat diet-induced obesity and systemic insulin resistance in mice. Oxid. Med. Cell. Longev. 2014, 965954 (2014).