Nifedipine (CAS 21829-25-4) | Cayman Chemical
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Nifedipine

Item № 11106
CAS № 21829-25-4
Purity ≥98%
product image
                (CAS 21829-25-4)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 g $15.00 0.00
     5 g $30.00 0.00
     10 g $50.00 0.00

Pricing updated 2019-02-20. Prices are subject to change without notice.

Description
Synonyms
  • BAY 1040

Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM.1 Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877) when administered at a dose of 10 mg/kg per day.2 It also reduces increases in mean arterial blood pressure induced by angiotensin II (Item No. 17150) in spontaneously hypertensive rats when administered at a dose of 10 μg/kg.3 Formulations containing nifedipine have been used in the treatment of hypertension and angina.

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Technical Information
Formal Name
1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3,5-dimethyl ester
CAS Number
21829-25-4
Synonyms
  • BAY 1040
Molecular Formula
C17H18N2O6
Formula Weight
346.3
Purity
≥98%
Formulation
A crystalline solid
λmax
236, 334, 360 nm
SMILES
CC1=C(C(OC)=O)C(C(C(OC)=O)=C(C)N1)C2=CC=CC=C2[N+]([O-])=O
InChI Code
InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
InChI Key
HYIMSNHJOBLJNT-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Ragy, M., and Elbassuoni, E. The role of nitric oxide and L-type calcium channel blocker in the contractility of rabbit ileum in vitro J. Physiol. Biochem. 68(4), 521-528 (2012).

2. Mukherjee, S., Ayaub, E., Murphy, J., et al. Disruption of calcium signaling in fibroblasts and attenuation of bleomycin-induced fibrosis by nifedipine Am. J. Respir. Cell Mol. Biol. 53(4), 450-458 (2015).

3. Aritomi, S., Konda, T., and Yoshimura, M. L/N-type calcium channel blocker suppresses reflex aldosterone production induced by antihypertensive action Heart Vessels 27(4), 419-423 (2012).

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