Pricing updated 2019-04-23. Prices are subject to change without notice.
Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM.1 Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877) when administered at a dose of 10 mg/kg per day.2 It also reduces increases in mean arterial blood pressure induced by angiotensin II (Item No. 17150) in spontaneously hypertensive rats when administered at a dose of 10 μg/kg.3 Formulations containing nifedipine have been used in the treatment of hypertension and angina.
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Ragy, M., and Elbassuoni, E. The role of nitric oxide and L-
Mukherjee, S., Ayaub, E., Murphy, J., et al. Disruption of calcium signaling in fibroblasts and attenuation of bleomycin-
Aritomi, S., Konda, T., and Yoshimura, M. L/N-