An active metabolite of nifedipine
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Parent Compound(s)
11106Nifedipine
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Dehydro Nifedipine

Item No. 23229

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,6-dimethyl-4-(2-nitrophenyl)-3,5-dimethyl ester 3,5-pyridinedicarboxylic acid
CAS Number
67035-22-7
Synonyms
  • BAY-b 4759
Molecular Formula
C17H16N2O6
Formula Weight
344.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.1 mg/mlEthanol: 3 mg/ml
λmax
260 nm
SMILES
CC1=C(C(OC)=O)C(C2=CC=CC=C2[N+]([O-])=O)=C(C(OC)=O)C(C)=N1
InChi Code
InChI=1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3
InChi Key
UMQHJQGNGLQJPF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    10 mg

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    Cayman Chemical
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    Product Description

    Dehydro nifedipine is an active metabolite of nifedipine (Item No. 11106), a calcium channel blocker present in formulations used to treat hypertension and angina.1,2,3,4 Dehydro nifedipine is formed when nifedipine is metabolized by the cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5.2 Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ardizzone, T.D., Lu, X.H., and Dwyer, D.S. Calcium-independent inhibition of glucose transport in PC-12 and L6 cells by calcium channel antagonists. Am. J. Physiol. Cell Physiol. 283(2), C579-586 (2002).

    2. Patki, K.C., Von Moltke, L.L., and Greenblatt, D.J. In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab. Dispos. 31(7), 938-944 (2003).

    3. Ago, T., Yang, Y., Zhai, P., et al. Nifedipine inhibits cardiac hypertrophy and left ventricular dysfunction in response to pressure overload. J. Cardiovasc. Transl. Res. 3(4), 304-313 (2010).

    4. Lemay, J., Tea, B.S., Hamet, P., et al. Regression of neointimal lesions in the carotid artery of nifedipine-treated SHR and WKY rats: Possible role of apoptosis. J. Vasc. Res. 38(5), 462-470 (2001).