A DNA methyltransferase inhibitor
Related Products
Contained In
11076Epigenetics Screening Library (96-Well)
Isomer(s)
43331MC3343
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SGI-1027

Item No. 11165

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)-benzamide
CAS Number
1020149-73-8
Synonyms
  • DNA Methyltransferase Inhibitor II
Molecular Formula
C27H23N7O
Formula Weight
461.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlDMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml
λmax
350 nm
SMILES
O=C(NC1=CC=C(NC2=NC(N)=NC(C)=C2)C=C1)C(C=C3)=CC=C3NC4=CC=NC5=C4C=CC=C5
InChi Code
InChI=1S/C27H23N7O/c1-17-16-25(34-27(28)30-17)32-20-10-12-21(13-11-20)33-26(35)18-6-8-19(9-7-18)31-24-14-15-29-23-5-3-2-4-22(23)24/h2-16H,1H3,(H,29,31)(H,33,35)(H3,28,30,32,34)
InChi Key
QSYLKMKIVWJAAK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

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    10 mg

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    50 mg

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    Product Description

    SGI-1027 is an inhibitor of the DNA methyltransferases DNMT1, DNMT3A, and DNMT3B (IC50s = 12.5, 8, and 7.5 μM, respectively, with Poly(dI-dC) as the substrate).1 It has been shown to cause the degradation of DNMT1 and to reactivate silenced tumor suppressor genes by reducing CpG island hypermethylation.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Datta, J., Ghoshal, K., Denny, W.A., et al. A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degredation. Cancer Res. 69(10), 4277-4285 (2009).