Lupeol

Lupeol, a dietary triterpene found in certain fruits, vegetables, and medicinal plants, has potent anti-inflammatory, anticarcinogenic, antimutagenic, and antimalarial activity. It suppresses the growth of hepatocellular carcinoma cell lines SMMC7721 and HepG2 with IC₅₀ values of 45 and 48.5 μM and melanoma cell lines Mel 928 and Mel 1241 with IC₅₀ values of 75 and 72 μM.^1,2 At 0.76 g/kg lupeol causes a significant decrease in the blood pressure of stroke-prone hypertensive rats and reduces expression of hepatic genes involved in triglyceride and cholesterol synthesis.³ It also has significant anti-inflammatory effects at 50 mg/kg in a carrageenan-induced edema model, inhibiting neutrophil migration.⁴

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1. Tarapore, R.S., Siddiqui, I.A., Saleem, M., et al. Specific targeting of Wnt/β-catenin signaling in human melanoma cells by a dietary triterpene lupeol. Carcinogenesis 31(10), 1844-1853 (2010).

2. He, Y., Liu, F., Zhang, L., et al. Growth inhibition and apoptosis induced by lupeol, a dietary triterpene, in human hepatocellular carcinoma cells. Bio. Pharm. Bull. 34(4), 517-522 (2011).

3. Ardiansyah, Yamaguchi, E., Shirakawa, H., et al. Lupeol supplementation improves blood pressure and lipid metabolism parameters in stroke-prone spontaneously hypertensive rats. Biosci. Biotechnol. Biochem. 76(1), 183-185 (2012).

4. Lucetti, D.L., Lucetti, E.C., Bandeira, M.A., et al. Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel. J. Inflamm. (Lond.) 7(60), 1-11 (2010).