An antibiotic that inhibits protein and DNA synthesis
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Anisomycin

Item No. 11308

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(4-methoxyphenyl)methyl]-3-acetate-(2R,3S,4S)-3,4-pyrrolidinediol
CAS Number
22862-76-6
Synonyms
  • Flagecidin
  • NSC 76712
  • Wuningmeisu C
Molecular Formula
C14H19NO4
Formula Weight
265.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 0.5 mg/ml
λmax
225, 277, 284 nm
SMILES
O[C@H]1CN[C@H](CC2=CC=C(OC)C=C2)[C@@H]1OC(C)=O
InChi Code
InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1
InChi Key
YKJYKKNCCRKFSL-RDBSUJKOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $38

    Add

    10 mg

    $44

    Add

    50 mg

    $147

    Add

    100 mg

    $255

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    Anisomycin is a pyrrolidine antibiotic produced by S. griseolus that inhibits protein and DNA synthesis.1 It activates stress-activated protein kinase, MAP kinase, and other signal transduction pathways. At 30 mg/kg, anisomycin displays immunosuppressive activity superior to that of Cyclosporine A, blocking T cell proliferation in skin-transplanted mice.2 Through a caspase-8-dependent pathway, anisomycin acts as a potent and specific anoikis sensitizer of malignant epithelial cells resistant to apoptosis upon detachment from the ECM, preventing distal tumor formation in a mouse model of prostate cancer metastases.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Grollman, A.P. Inhibitors of protein biosynthesis. The Journal of Biological Chemisty 242(13), 3226-3233 (1967).

    2. Xing, F., Yu, Z., Liu, J., et al. Anisomycin inhibits the behaviors of T cells and the allogeneic skin transplantation in mice. J. Immunother. 31(9), 858-870 (2008).

    3. Mawji, I.A., Simpson, C.D., Gronda, M., et al. A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis. Cancer Res. 67(17), 8307-8315 (2007).