A chemical chaperone
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Labeled Version(s)
22085Sodium 4-Phenylbutyrate-d11
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Sodium 4-Phenylbutyrate

Item No. 11323

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
benzenebutanoic acid, monosodium salt
CAS Number
1716-12-7
Synonyms
  • Benzenebutanoic Acid
  • NSC 657802
  • TriButyrate
Molecular Formula
C10H11O2 • Na
Formula Weight
186.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.33 mg/mlDMSO: 1.6 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
O=C(CCCC1=CC=CC=C1)[O-].[Na+]
InChi Code
InChI=1S/C10H12O2.Na/c11-10(12)8-4-7-9-5-2-1-3-6-9;/h1-3,5-6H,4,7-8H2,(H,11,12);/q;+1/p-1
InChi Key
VPZRWNZGLKXFOE-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $45

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    10 g

    $180

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    Cayman Chemical
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    Product Description

    Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.1,2 It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.3,4 Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stewart, G.A., Ridscale, R., Martin, E.P., et al. 4-Phenylbutyric acid treatment rescues trafficking and processing of a mutant surfactant protein-C. Am. J. Respir. Cell Mol. Biol. 47(3), 324-331 (2012).

    2. Bradbury, N.A. Focus on "sodium 4-phenylbutyrate downregulates Hsc70: Implications for intracellular trafficking of ΔF508-CFTR". Am. J. Physiol. Cell Physiol. 278(2), C257-C258 (2000).

    3. Lu, Q., Wang, D.S., Chen, C.S., et al. Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J. Med. Chem. 48(17), 5530-5535 (2005).

    4. Ammerpohl, O., Trauzold, A., Schniewind, B., et al. Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells. Br. J. Cancer 96(1), 73-81 (2007).