A natural phytochemical
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Indole-3-carbinol

Item No. 11325

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1H-indole-3-methanol
CAS Number
700-06-1
Synonyms
  • 3-hydroxymethyl Indole
  • I3C
  • Indinol
  • 1H-Indole-3-methanol
  • 3-Indolylmethanol
  • NSC 525801
Molecular Formula
C9H9NO
Formula Weight
147.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 3 mg/mlEthanol: 10 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
220, 279 nm
SMILES
OCC1=CNC2=C1C=CC=C2
InChi Code
InChI=1S/C9H9NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-5,10-11H,6H2
InChi Key
IVYPNXXAYMYVSP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 g

    $22

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    5 g

    $69

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    10 g

    $123

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    25 g

    $229

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    Cayman Chemical
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    Product Description

    Indole-3-carbinol (I3C) is a natural phytochemical produced in crucifers by the action of myrosinase on glucobrassinin.1 It has been shown to have anti-cancer effects, at least in part through inhibition of NF-κB and Akt signaling pathways.2 I3C may undergo a condensation reaction in vivo, leading to the production of 3,3’-diindolylmethane (Item No. 15927), which alters the expression of oncogenes and tumor suppressor genes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bradlow, H.L. Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer. In vivo 22(4), 441-445 (2008).

    2. Sarkar, F.H., Li, Y., Wang, Z., et al. Cellular signaling perturbation by natural products. Cell Signal. 21(11), (2009).

    3. Phuah, N.H., and Nagoor, N.H. Regulation of microRNAs by natural agents: new strategies in cancer therapies. Biomed. Res. Int. 2014:804510, (2014).