A natural phytochemical
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Indole-3-carbinol

Item No. 11325

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1H-indole-3-methanol
CAS Number
700-06-1
Synonyms
  • 3-hydroxymethyl Indole
  • I3C
  • Indinol
  • 1H-Indole-3-methanol
  • 3-Indolylmethanol
  • NSC 525801
Molecular Formula
C9H9NO
Formula Weight
147.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 3 mg/mlEthanol: 10 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
220, 279 nm
SMILES
OCC1=CNC2=C1C=CC=C2
InChi Code
InChI=1S/C9H9NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-5,10-11H,6H2
InChi Key
IVYPNXXAYMYVSP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 g

    $22

    Add

    5 g

    $69

    Add

    10 g

    $123

    Add

    25 g

    $229

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Indole-3-carbinol (I3C) is a natural phytochemical produced in crucifers by the action of myrosinase on glucobrassinin.1 It has been shown to have anti-cancer effects, at least in part through inhibition of NF-κB and Akt signaling pathways.2 I3C may undergo a condensation reaction in vivo, leading to the production of 3,3’-diindolylmethane (Item No. 15927), which alters the expression of oncogenes and tumor suppressor genes.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bradlow, H.L. Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer. In vivo 22(4), 441-445 (2008).

    2. Sarkar, F.H., Li, Y., Wang, Z., et al. Cellular signaling perturbation by natural products. Cell Signal. 21(11), (2009).

    3. Phuah, N.H., and Nagoor, N.H. Regulation of microRNAs by natural agents: new strategies in cancer therapies. Biomed. Res. Int. 2014:804510, (2014).