A natural mycotoxin
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Isomer(s)
114293-Acetyldeoxy Nivalenol
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Product Type

Environmental Toxicology
Toxins
Mycotoxins

15-Acetyldeoxy Nivalenol

Item No. 11430

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
15-(acetyloxy)-12,13-epoxy-3α,7α-dihydroxy-trichothec-9-en-8-one
CAS Number
88337-96-6
Synonyms
  • 15-Acetyl Vomitoxin
  • 15-AcDON
  • Deoxynivalenol 15-acetate
  • DON 15-acetate
Molecular Formula
C17H22O7
Formula Weight
338.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleEthanol: Soluble
SMILES
CC1=C[C@]2([H])[C@]([C@](C[C@H]3O)(C)C4(OC4)[C@]3([H])O2)(COC(C)=O)[C@H](O)C1=O
InChi Code
InChI=1S/C17H22O7/c1-8-4-11-16(6-22-9(2)18,13(21)12(8)20)15(3)5-10(19)14(24-11)17(15)7-23-17/h4,10-11,13-14,19,21H,5-7H2,1-3H3/t10-,11-,13-,14-,15-,16-,17?/m1/s1
InChi Key
IDGRYIRJIFKTAN-KLOHDQKESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $103

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    Product Description

    15-Acetyldeoxy nivalenol is a trichothecene mycotoxin produced by certain species of the fungus Fusarium, particularly those found on cereal crops.1 It is an acetylated derivative of 4-deoxy nivalenol (DON; Item No. 11428) that can be converted to DON in the body. 15-Acetyldeoxy nivalenol induces vomiting and anorexia in livestock and experimental animals and its toxicity compared with DON is dependent upon the route of administration.2,3 It also changes brain bioamine neurotransmitter levels in pigs and chickens.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ajandouz, E.H., Berdah, S., Moutardier, V., et al. Hydrolytic fate of 3/15-acetyldeoxynivalenol in humans: Specific deacetylation by the small intestine and liver revealed using in vitro and ex vivo approaches. Toxins (Basel) 8(8), E232 (2016).

    2. Pestka, J.J., Lin, W.-S., and Miller, E.R. Emetic activity of the trichothecene 15-acetyldeoxynivalenol in swine. Food Chem. Toxicol. 25(11), 855-888 (1987).

    3. Payros, D., Alazzane-Kpembi, I., Pierron, A., et al. Toxicology of deoxynivalenol and its acetylated and modified forms. Arch. Toxicol. 90(12), 2931-2957 (2016).

    4. Bonnet, M.S., Roux, J., Mounien, L., et al. Advances in deoxynivalenol toxicity mechanisms: The brain as a target. Toxins (Basel) 4(11), 1120-1138 (2012).