A trichothecene mycotoxin
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Labeled Version(s)
3125913C15-Nivalenol
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Product Categories

Product Type

Environmental Toxicology
Toxins
Mycotoxins

Nivalenol

Item No. 11438

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,4β,7α)-12,13-epoxy-3,4,7,15-tetrahydroxy-trichothec-9-en-8-one
CAS Number
23282-20-4
Synonyms
  • NSC 269143
Molecular Formula
C15H20O7
Formula Weight
312.3
Purity
≥98%
Formulation
A crystalline powder
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
220 nm
SMILES
CC1=C[C@]2([H])[C@]([C@]3(C)[C@@]4(OC4)[C@]([C@H](O)[C@H]3O)([H])O2)(CO)[C@H](O)C1=O
InChi Code
InChI=1S/C15H20O7/c1-6-3-7-14(4-16,11(20)8(6)17)13(2)10(19)9(18)12(22-7)15(13)5-21-15/h3,7,9-12,16,18-20H,4-5H2,1-2H3/t7-,9-,10-,11-,12-,13-,14-,15+/m1/s1
InChi Key
UKOTXHQERFPCBU-XBXCNEFVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Nivalenol is a trichothecene mycotoxin that has been found in Fusarium.1 It is lethal to mice (LD50 = 6.9 mg/kg).2 Nivalenol (5, 10, and 15 mg/kg) also induces thymic, splenic, and Peyer's patch cell apoptosis in mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, Z., Concannon, J., Ng, K.S., et al. Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulation. Sci. Rep. 6, 30263 (2016).

    2. Yoshizawa, T., and Morooka, N. Studies on the toxic substances in the infected cereals (part 3): Acute toxicities of new trichothecene mycotoxins: Deoxynivalenol and its monoacetate. J. Food Hyg. 15(4), 261-269 (1974).

    3. Poapolathep, A., Ohtsuka, R., Kiatipattanasakul, W., et al. Nivalenol-induced apoptosis in thymus, spleen and Peyer’s patches of mice. Exp. Toxicol. Pathol. 53(6), 441-446 (2002).