A mycotoxin that inhibits quorum sensing
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Penicillic Acid

Item No. 11440

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methoxy-5-methyl-4-oxo-2,5-hexadienoic acid
CAS Number
90-65-3
Synonyms
  • NSC 402844
Molecular Formula
C8H10O4
Formula Weight
170.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
224 nm
SMILES
C=C(C)C(/C(OC)=C\C(O)=O)=O
InChi Code
InChI=1S/C8H10O4/c1-5(2)8(11)6(12-3)4-7(9)10/h4H,1H2,2-3H3,(H,9,10)/b6-4+
InChi Key
VOUGEZYPVGAPBB-GQCTYLIASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

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    25 mg

    $238

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    Cayman Chemical
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    Product Description

    Penicillic acid is a mycotoxin produced from Penicillium species identified in molds on corn and other grains. At 80 μM, penicillic acid inhibits bacterial quorum sensing communication in P. aeruginosa by selectively repressing various virulence factor and other quorum sensing-regulated genes.1 It has been shown to inhibit Fas-mediated apoptosis at 100-200 μM by targeting caspase-8 activity in Burkitt’s lymphoma Raji cells.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rasmussen, T.B., Skindersoe, M.E., Bjarnsholt, T., et al. Identity and effects of quorum-sensing inhibitors produced by Penicillium species. Microbiology 151, 1325-1340 (2005).

    2. Bando, M., Hasegawa, M., Tsuboi, Y., et al. The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex. The Journal of Biological Chemisty 278(8), 5786-5793 (2003).