An inhibitor of Bcl-2 family proteins
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Labeled Version(s)
34694ABT-263-d8
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ABT-263

Item No. 11500

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-benzamide
CAS Number
923564-51-6
Synonyms
  • A-855071
  • Navitoclax
Molecular Formula
C47H55ClF3N5O6S3
Formula Weight
974.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH7.2) (1:2): 0.3 mg/mlDMSO: 25 mg/mlEthanol: 0.5 mg/ml
λmax
279, 320 nm
SMILES
O=C(NS(C1=CC(S(=O)(C(F)(F)F)=O)=C(N[C@H](CCN2CCOCC2)CSC3=CC=CC=C3)C=C1)(=O)=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4
InChi Code
InChI=1S/C47H55ClF3N5O6S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-55-22-24-56(25-23-55)39-14-10-35(11-15-39)45(57)53-65(60,61)41-16-17-43(44(30-41)64(58,59)47(49,50)51)52-38(19-21-54-26-28-62-29-27-54)33-63-40-6-4-3-5-7-40/h3-17,30,38,52H,18-29,31-33H2,1-2H3,(H,53,57)/t38-/m1/s1
InChi Key
JLYAXFNOILIKPP-KXQOOQHDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    ABT-263 is an inhibitor of the Bcl-2 family proteins Bcl-2, Bcl-xL, and Bcl-W (Kis = <1, <0.5, and <1 nM, respectively).1 It is selective for Bcl-2, Bcl-xL, and Bcl-W over Mcl-1 and A1 (Kis = 550 and 354 nM, respectively). ABT-263 is cytotoxic in a panel of small cell lung cancer (SCLC), leukemia, and lymphoma cell lines with a mean EC50 value of 1 µM. It induces apoptosis in influenza A-infected retinal pigment epithelial cells (EC50 = 0.08 µM).2 ABT-263 (100 mg/kg) induces tumor regression in NCI H146 SCLC and RS4;11 acute lymphocytic leukemia (ALL) mouse xenograft models.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tse, C., Shoemaker, A.R., Adickes, J., et al. ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 68(9), 3421-3428 (2008).

    2. Bulanova, D., Ianevski, A., Bugai, A., et al. Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins. Viruses 9(10), E271 (2017).

    3. Shoemaker, A.R., Mitten, M.J., Adickes, S., et al. Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models. Clin. Cancer Res. 14(11), 3268-3277 (2008).