An internal standard for the quantification of ABT-263
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Unlabeled Version(s)
11500ABT-263
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ABT-263-d8

Item No. 34694

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl-d8)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-benzamide
CAS Number
1217620-38-6
Synonyms
  • Navitoclax-d8
Molecular Formula
C47H47ClD8F3N5O6S3
Formula Weight
982.7
Purity
≥99% deuterated forms (d1-d8)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:2): 0.3 mg/mlDMSO: 25 mg/mlEthanol: 0.5 mg/ml
SMILES
CC(C)(C1)CCC(C2=CC=C(C=C2)Cl)=C1CN3CCN(C4=CC=C(C=C4)C(NS(=O)(C5=CC(S(C(F)(F)F)(=O)=O)=C(C=C5)N[C@@H](CSC6=CC=CC=C6)CCN7C([2H])([2H])C([2H])([2H])OC([2H])([2H])C7([2H])[2H])=O)=O)CC3
InChi Code
InChI=1S/C47H55ClF3N5O6S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-55-22-24-56(25-23-55)39-14-10-35(11-15-39)45(57)53-65(60,61)41-16-17-43(44(30-41)64(58,59)47(49,50)51)52-38(19-21-54-26-28-62-29-27-54)33-63-40-6-4-3-5-7-40/h3-17,30,38,52H,18-29,31-33H2,1-2H3,(H,53,57)/t38-/m1/s1/i26D2,27D2,28D2,29D2
InChi Key
JLYAXFNOILIKPP-YSUYZUONSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $128

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    1 mg

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    5 mg

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    Cayman Chemical
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    Product Description

    ABT-263-d8 is intended for use as an internal standard for the quantification of ABT-263 (Item No. 11500) by GC- or LC-MS. ABT-263 is an inhibitor of the Bcl-2 family proteins Bcl-2, Bcl-xL, and Bcl-W (Kis = <1, <0.5, and <1 nM, respectively).1 It is selective for Bcl-2, Bcl-xL, and Bcl-W over Mcl-1 and A1 (Kis = 550 and 354 nM, respectively). ABT-263 is cytotoxic in a panel of small cell lung cancer (SCLC), leukemia, and lymphoma cell lines with a mean EC50 value of 1 µM. It induces apoptosis in influenza A-infected retinal pigment epithelial cells (EC50 = 0.08 µM).2 ABT-263 (100 mg/kg) induces tumor regression in NCI H146 SCLC and RS4;11 acute lymphocytic leukemia (ALL) mouse xenograft models.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tse, C., Shoemaker, A.R., Adickes, J., et al. ABT-263: A potent and orally bioavailable Bcl-2 family inhibitor. Cancer Res. 68(9), 3421-3428 (2008).

    2. Bulanova, D., Ianevski, A., Bugai, A., et al. Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteins. Viruses 9(10), E271 (2017).

    3. Shoemaker, A.R., Mitten, M.J., Adickes, S., et al. Activity of the Bcl-2 family inhibitor ABT-263 in a panel of small cell lung cancer xenograft models. Clin. Cancer Res. 14(11), 3268-3277 (2008).