An angiotensin II type 1 receptor antagonist
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Eprosartan (mesylate)

Item No. 11578

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(αE)-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophenepropanoic acid, mesylate
CAS Number
144143-96-4
Synonyms
  • SKF 108566J
Molecular Formula
C23H24N2O4S • CH3SO3H
Formula Weight
520.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 1 mg/ml
λmax
233, 271 nm
SMILES
CCCCC1=NC=C(/C=C(CC2=CC=CS2)/C(O)=O)N1CC3=CC=C(C(O)=O)C=C3.O=S(O)(C)=O
InChi Code
InChI=1S/C23H24N2O4S.CH4O3S/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-30-20)25(21)15-16-7-9-17(10-8-16)22(26)27;1-5(2,3)4/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)(H,28,29);1H3,(H,2,3,4)/b18-12+;
InChi Key
DJSLTDBPKHORNY-XMMWENQYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $55

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    50 mg

    $169

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    100 mg

    $295

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    Product Description

    Eprosartan (mesylate) is a competitive AT1 receptor antagonist with IC50 values ranging from 1.4 – 3.9 nM and an elimination half-life of five to seven hours.1 Eprosartan is structurally distinct from other noncompetitive ARBs in that it does not contain a biphenyl, tetrazole moiety and blocks angiotensin II receptors on both sympathetic nerve terminals and blood vessels.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Burnier, M. Angiotensin II type 1 receptor blockers. Circulation 103(6), 904-912 (2001).

    2. Blankestijn, P.J., and Rupp, H. Clinical profile of eprosartan: A different angiotensin II receptor blocker. Cardiovasc. Hematol. Agents Med. Chem. 6(4), 253-257 (2008).