A noncytotoxic natural diterpenoid
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Isomer(s)
3322520-Deoxyingenol
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14-deoxy-11,12-didehydro Andrographolide

Item No. 11670

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(1E)-2-[(1R,4aS,5R,6R,8aR)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethenyl]-2(5H)-furanone
CAS Number
42895-58-9
Synonyms
  • 14-dehydro Andrographolide
Molecular Formula
C20H28O4
Formula Weight
332.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 2 mg/ml
λmax
247 nm
SMILES
C=C1CC[C@]2([H])[C@@](CO)(C)[C@H](O)CC[C@@]2(C)[C@@H]1/C=C/C3=CCOC3=O
InChi Code
InChI=1S/C20H28O4/c1-13-4-7-16-19(2,10-8-17(22)20(16,3)12-21)15(13)6-5-14-9-11-24-18(14)23/h5-6,9,15-17,21-22H,1,4,7-8,10-12H2,2-3H3/b6-5+/t15-,16+,17-,19+,20+/m1/s1
InChi Key
XMJAJFVLHDIEHF-CRBRZBHVSA-N
Origin
Plant/Andrographis paniculata
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    14-deoxy-11,12-didehydro Andrographolide is an analog of the natural diterpenoid andrographolide (Item No. 11679) that can be isolated from A. paniculata.1 It retains the anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities of andrographolide without producing cytotoxicity in KB cells (ED50 >20 µg/ml) that can occur with andrographolide 6.5 µg/ml.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, W., Xu, X., Zhang, H., et al. Secondary metabolites from Andrographis paniculata. Chem. Pharm. Bull. (Tokyo) 55(3), 455-458 (2007).

    2. Jarukamjorn, K., and Nemoto, N. Pharmacological aspects of Andrographis paniculata on health and its major diterpenoid constituent andrographolide. J. Health Sci. 54(4), 370-381 (2008).