A diterpenoid with antioxidant and osteoprotective activities
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20-Deoxyingenol

Item No. 33225

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1aR,2S,5R,5aS,6S,9,10,10aR-octahydro-5,5a,6-trihydroxy-1,1,4,7,9R-pentamethyl-1H-2,8aS-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one
CAS Number
54706-99-9
Molecular Formula
C20H28O4
Formula Weight
332.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/ml
SMILES
O[C@@H](C(C)=C[C@]12[C@@H](C[C@@]34[H])C)[C@@]2(O)[C@@H](C(C)=C[C@@H](C1=O)[C@@]4(C3(C)C)[H])O
InChi Code
InChI=1S/C20H28O4/c1-9-6-12-14-13(18(14,4)5)7-11(3)19(17(12)23)8-10(2)16(22)20(19,24)15(9)21/h6,8,11-16,21-22,24H,7H2,1-5H3/t11-,12-,13-,14+,15-,16+,19+,20+/m1/s1
InChi Key
FOSYZKSOJUQLTD-VCQBTUPJSA-N
Origin
Plant/Herba Epimedii
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    20-Deoxyingenol is a diterpenoid that has been found in E. kansui and has antioxidant and osteoprotective activities.1,2 It inhibits oxidative stress-induced decreases in autophagic flux and apoptosis in isolated mouse chondrocytes when used at a concentration of 10 mM.2 20-Deoxyingenol (20 mg/kg per day, i.p.) reduces bone erosion and cartilage calcification in joints in a mouse model of injury-induced osteoarthritis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, J.-S., Weng, H.-Z., Huang, J.-L., et al. Anti-inflammatory ingenane diterpenoids from the roots of Euphorbia kansui. Planta Med. 84(18), 1334-1339 (2018).

    2. Gu, M., Jin, J., Ren, C., et al. 20-Deoxyingenol alleviates osteoarthritis by activating TFEB in chondrocytes. Pharmacol. Res. 165, 105361 (2021).