An inhibitor of HMG-CoA reductase and CYP450 isoforms
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Isomer(s)
29394Elemicin
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α-Asarone

Item No. 11681

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,4-trimethoxy-5-(1E)-1-propen-1-yl-benzene
CAS Number
2883-98-9
Synonyms
  • trans-Asarone
Molecular Formula
C12H16O3
Formula Weight
208.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 11 mg/mlEthanol: 14 mg/ml
λmax
212, 258, 313 nm
SMILES
COC1=CC(/C=C/C)=C(OC)C=C1OC
InChi Code
InChI=1S/C12H16O3/c1-5-6-9-7-11(14-3)12(15-4)8-10(9)13-2/h5-8H,1-4H3/b6-5+
InChi Key
RKFAZBXYICVSKP-AATRIKPKSA-N
Origin
Plant/Acorus calamus
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $29

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    1 g

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    5 g

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    Product Description

    α-Asarone is a component of certain essential oils used in traditional Chinese herbal medicine. Although carcinogenic, α-asarone has been shown to be neuroprotective and radioprotective in mice when given at 50 mg/kg.1,2,3 It also lowers serum cholesterol in rats, specifically reducing LDL-cholesterol levels and cholesterol saturation index, by directly inhibiting HMG-CoA reductase (IC50 = 3 mM).4,5 α-Asarone also directly interacts with and inhibits certain isoforms of cytochrome P450 (IC50 = 55.2 and 65.2 μg/ml for CYP2D6 and CYP3A4, respectively).6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Limón, I.D., Mendieta, L., Díaz, A., et al. Neuroprotective effect of alpha-asarone on spatial memory and nitric oxide levels in rats injected with amyloid-β(25-35). Neurosci. Lett. 453(2), 98-103 (2009).

    2. Sandeep, D., and Nair, C.K. Radioprotection by α-asarone: Prevention of genotoxicity and hematopoietic injury in mammalian organism. Mutat. Res. 722(1), 62-68 (2011).

    3. Zuo, H.L., Yang, F.Q., Zhang, X.M., et al. Separation of cis- and trans-Asarone from Acorus tatarinowii by preparative gas chromatography. J. Anal. Methods Chem. 402081 (2012).

    4. Rodríguez-Páez, L., Juárez-Sanchez, M., Antúnez-Solís, J., et al. α-Asarone inhibits HMG-CoA reductase, lowers serum LDL-cholesterol levels and reduces biliary CSI in hypercholesterolemic rats. Phytomedicine 10(5), 397-404 (2003).

    5. Antunez-Solis, J., Hernández-Derramadero, F., Aquino-Vega, M., et al. 2,4,5-trimethoxycinnamic acid: The major metabolite of α-asarone, retains most of the pharmacological properties of α-asarone. J. Enzyme Inhib. Med. Chem. 24(3), 903-909 (2009).

    6. Pandit, S., Mukherjee, P.K., Ponnusankar, S., et al. Metabolism mediated interaction of α-asarone and Acorus calamus with CYP3A4 and CYP2D6. Fitoterapia 82(3), 369-374 (2011).