GW 6471

GW 6471 is an antagonist of PPARα (IC₅₀ = 240 nM).¹ It drives the displacement of coactivators from PPARα and promotes the recruitment of co-repressor proteins like nuclear co-repressor.¹ GW 6471 is used in cell-free, cell lysate, and whole cell systems to examine the impact of PPARα antagonism.^2,3,4

WARNING This product is not for human or veterinary use.

1. Xu, H.E., Stanley, T.B., Montana, V.G., et al. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα. Nature 415(6873), 813-817 (2002).

2. Wang, W., Lin, Q., Lin, R., et al. PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway. Exp. Cell Res. 319(10), 1523-1533 (2013).

3. Downer, E.J., Clifford, E., Amu, S., et al. The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α. The Journal of Biological Chemisty 287(30), 25440-25453 (2012).

4. Müller, M.Q., de Koning, L.I., Schmidt, A., et al. An innovative method to study target protein-drug interactions by mass spectrometry. J. Med. Chem. 52(9), 2875-2879 (2009).