A P-glycoprotein inhibitor
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Hypophyllanthin

Item No. 11715

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(7S,8S,9R)-9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-naphtho[1,2-d]-1,3-dioxole
CAS Number
33676-00-5
Synonyms
  • NSC 619044
Molecular Formula
C24H30O7
Formula Weight
430.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 10 mg/mlEthanol: 0.2 mg/ml
SMILES
COC[C@@H]1[C@@H](COC)CC(C=C(OC)C2=C3OCO2)=C3[C@H]1C4=CC(OC)=C(OC)C=C4
InChi Code
InChI=1S/C24H30O7/c1-25-11-16-8-15-10-20(29-5)23-24(31-13-30-23)22(15)21(17(16)12-26-2)14-6-7-18(27-3)19(9-14)28-4/h6-7,9-10,16-17,21H,8,11-13H2,1-5H3/t16-,17-,21+/m1/s1
InChi Key
LBJCUHLNHSKZBW-LZJOCLMNSA-N
Origin
Plant/Phyllanthus amarus
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $69

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    5 mg

    $297

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    10 mg

    $493

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    25 mg

    $1,062

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    Product Description

    Hypophyllanthin is an active principle of P. amarus, a plant studied for its potential to treat hepatotoxicity.1 In Caco-2 cells 100 µM hypophyllanthin has been shown to reversibly inhibit P-glycoprotein (also known as multidrug resistance protein 1 (MDR1)) function without effect on MDR2 activity.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Murali, B., Amit, A., Anand, M.S., et al. An improved HPLC method for estimation of phyllanthin and hypophyllanthin in Phyllanthus amarus. Journal of Natural Remedies 1(1), 55-59 (2001).

    2. Sukhaphirom, N., Vardhanabhuti, N., Chirdchupunseree, H., et al. Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells. J. Pharm. Pharmacol. 65, 292-299 (2012).