A lignin with diverse biological activities
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Isomer(s)
37287Paulownin
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Sesamolin

Item No. 11754

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(1S,3aR,4R,6aR)-4-(1,3-benzodioxol-5-yloxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-1,3-benzodioxole
CAS Number
526-07-8
Molecular Formula
C20H18O7
Formula Weight
370.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mLDMSO: 12 mg/mLDMSO:PBS (pH 7.2) (1:10): 50 µg/mLEthanol: 0.5 mg/mL
λmax
237, 289 nm
SMILES
[H][C@]1(CO2)[C@@](CO[C@@H]1C3=CC=C(OCO4)C4=C3)([H])[C@H]2OC5=CC=C6C(OCO6)=C5
InChi Code
InChI=1S/C20H18O7/c1-3-15-17(25-9-23-15)5-11(1)19-13-7-22-20(14(13)8-21-19)27-12-2-4-16-18(6-12)26-10-24-16/h1-6,13-14,19-20H,7-10H2/t13-,14-,19+,20+/m0/s1
InChi Key
ZZMNWJVJUKMZJY-AFHBHXEDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Sesamolin is a lignin found in S. indicum with diverse biological activities. It reduces lipid peroxidation in rat liver and kidneys in vivo but has no effect on lipid peroxidation activity of rat liver microsomes in vitro.1 In vivo, sesamolin reduces epididymal white adipose tissue weight and serum triacylglcerol, free fatty acid, phospholipid, and cholesterol concentrations in rats.2 Sesamolin inhibits growth of Molt-4B human lymphoid leukemia cells via induction of apoptosis in a dose-dependent manner.3 It also reduces hypoxia-induced lactate hydrogenase (LDH) release and dichlorofluorescin-sensitive reactive oxygen species (ROS) production in BV-2 microglia grown under hypoxic conditions.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ide, T., Lim, J.S., Odbayer, T.O., et al. Comparative study of sesame lignans (sesamin, episesamin and sesamolin) affecting gene expression profile and fatty acid oxidation in rat liver. J. Nutr. Sci. Vitaminol. (Tokyo) 55(1), 31-43 (2009).