A saponin with significant wound healing activity
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Asiaticoside

Item No. 11819

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2α,3β,23-trihydroxy-urs-12-en-28-oic acid, O-6-deoxy-α-L-mannopyranosyl-(1→4α)-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl ester
CAS Number
16830-15-2
Synonyms
  • Ba 2742
  • NSC 36002
  • NSC 166062
Molecular Formula
C48H78O19
Formula Weight
959.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC[C@]1(C)[C@@H](O)[C@H](O)C[C@@]2(C)[C@@]1([H])CC[C@]3(C)[C@]2([H])CC=C4[C@@]3(C)CC[C@]5(C(O[C@@H]6O[C@H](CO[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@]8([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@@H](CO)O7)[C@@H](O)[C@H](O)[C@H]6O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5
InChi Code
InChI=1S/C48H78O19/c1-20-10-13-48(15-14-46(6)23(29(48)21(20)2)8-9-28-44(4)16-24(51)39(60)45(5,19-50)27(44)11-12-47(28,46)7)43(61)67-42-36(58)33(55)31(53)26(65-42)18-62-40-37(59)34(56)38(25(17-49)64-40)66-41-35(57)32(54)30(52)22(3)63-41/h8,20-22,24-42,49-60H,9-19H2,1-7H3/t20-,21+,22+,24-,25-,26-,27-,28-,29+,30+,31-,32-,33+,34-,35-,36-,37-,38-,39+,40-,41+,42+,44+,45+,46-,47-,48+/m1/s1
InChi Key
WYQVAPGDARQUBT-FGWHUCSPSA-N
Origin
Plant/Centella asiatica
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $41

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    10 mg

    $75

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    50 mg

    $312

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    Product Description

    Asiaticoside is the main saponin constituent of C. asiatica, a plant long used in the Ayurvedic system of medicine to treat a variety of ailments including dermatitis, diabetes, cough, cataract, hypertension, as well as for wound healing and improving memory. In various wound healing models, topical application (0.2-0.4%), injection (1 mg), or ingestion (1 mg/kg) of asiaticoside has been shown to increase hydroxyproline content, improve tensile strength, increase collagen synthesis and remodeling of the collagen matrix, promote epithelialization, stimulate glycosaminoglycan synthesis, and elevate antioxidant levels.1,2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Somboonwong, J., Kankaisre, M., Tantisira, B., et al. Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: An experimental animal study. BMC Complement. Altern. Med. 12(103), (2012).

    2. Maquart, F.X., Chastang, F., Simeon, A., et al. Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. Eur. J. Dermatol. 9(4), 289-296 (1999).

    3. Rasik, A.M., and Shukla, A. Antioxidant status in delayed healing type of wounds. Int. J. Exp. Pathol. 81(4), 257-263 (2000).

    4. Shukla, A., Rasik, A.M., Jain, G.K., et al. In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J. Ethnopharmacol. 65(1), 1-11 (1999).