A triterpenoid saponin with diverse biological activities
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Isomer(s)
11851Bacopaside X
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Bacopasaponin C

Item No. 11820

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S,2R,4aR,6aS,6bR,8aR,10S,12aR,12bR,14aR,14bS)-hexadecahydro-1-hydroxy-1,6b,9,9,12a-pentamethyl-2-(2-methyl-1-propen-1-yl)-4a,6a-methano-1H,6H-phenanthro[2,1-d]pyrano[2,3-b]pyran-10-yl O-α-L-arabinofuranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→3)]-α-L-arabinopyranoside
CAS Number
178064-13-6
Synonyms
  • (–)-Bacopasaponin C
Molecular Formula
C46H74O17
Formula Weight
899.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
O[C@@H]1[C@@H](O)[C@H](CO)O[C@@]1([H])O[C@@H]2[C@@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H](O)CO[C@@]2([H])O[C@H]4CC[C@@]5(C)[C@](CC[C@]6(C)[C@]5([H])CC[C@@]7([H])[C@@]68C[C@@]9(OC8)[C@]7([H])[C@@](C)(O)[C@H](/C=C(C)\C)CO9)([H])C4(C)C
InChi Code
InChI=1S/C46H74O17/c1-21(2)14-22-17-57-46-19-45(20-58-46)23(37(46)44(22,7)55)8-9-28-42(5)12-11-29(41(3,4)27(42)10-13-43(28,45)6)61-40-36(63-38-33(53)31(51)26(16-48)60-38)35(24(49)18-56-40)62-39-34(54)32(52)30(50)25(15-47)59-39/h14,22-40,47-55H,8-13,1
InChi Key
ZOFQVMPJZHCDBS-MUUHSGPCSA-N
Origin
Plant/Bacopa monnieri (L.)
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $105

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    Product Description

    Bacopasaponin C is a triterpenoid saponin originally isolated from B. monniera that has diverse biological activities.1,2,3 It inhibits the ATPase activity of P-glycoprotein (IC50 = 57.83 µg/ml).4 Bacopasaponin C inhibits scopolamine-induced impairments in spatial memory in the Morris water maze and memory retrieval in the step-down test in mice when administered at a dose of 50 mg/kg.1 It also decreases the time mice spent immobile in the forced swim and tail suspension tests, indicating antidepressant-like activity.2 Bacopasaponin C reduces the spleen parasite load in a hamster model of leishmaniasis when administered as a free compound or in liposomal, niosomal, microencapsulated, or nanocapsulated forms.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhou, Y., Peng, L., Zhang, W.-D., et al. Effect of triterpenoid saponins from Bacopa monniera on scopolamine-induced memory impairment in mice. Planta Med. 75(6), 568-574 (2009).

    2. Zhou, Y., Shen, Y.-H., Zhang, C., et al. Triterpene saponins from Bacopa monnieri and their antidepressant effects in two mice models. J. Nat. Prod. 70(4), 652-655 (2007).

    3. Sinha, J., Raay, B., Das, N., et al. Bacopasaponin C: Critical evaluation of anti-leishmanial properties in various delivery modes. Drug Deliv. 9(1), 55-62 (2002).

    4. Singh, R., Rachumallu, R., Bhateria, M., et al. In vitro effects of standardized extract of Bacopa monniera and its five individual active constituents on human P-glycoprotein activity. Xenobiotica 45(8), 741-749 (2015).