A natural steroid saponin
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Isomer(s)
40279Isoastragaloside I
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Dioscin

Item No. 11834

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→4)]-β-D-glucopyranoside
CAS Number
19057-60-4
Synonyms
  • Collettiside III
Molecular Formula
C45H72O16
Formula Weight
869.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.3 mg/mlEthanol: 10 mg/ml
λmax
202 nm
SMILES
C[C@H](CC1)CO[C@]21O[C@@]3([H])C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](O[C@]7([H])O[C@H](CO)[C@@H](O[C@@]8([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O8)[C@H](O)[C@H]7O[C@@]9([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O9)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@@]3([H])[C@@H]2C
InChi Code
InChI=1S/C45H72O16/c1-19-9-14-45(54-18-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(52)34(50)32(48)22(4)56-41)37(53)38(29(17-46)58-42)59-40-35(51)33(49)31(47)21(3)55-40/h7,19-22,24-42,46-53H,8-18H2,1-6H3/t19-,20+,21+,22+,24+,25-,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36-,37+,38-,39-,40+,41+,42-,43+,44+,45-/m1/s1
InChi Key
VNONINPVFQTJOC-ZGXDEBHDSA-N
Origin
Plant/Trigonella foenum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $134

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    25 mg

    $283

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    50 mg

    $530

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    100 mg

    $926

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    Cayman Chemical
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    Product Description

    Dioscin is a natural steroid saponin that was first isolated from plants used in herbal remedies.1 Early studies indicated that it inhibits proliferation and induces apoptosis in cancer cells.2,3 Dioscin has antioxidant activity that can alter cell signaling in cancer cells.4,5 It also induces autophagy prior to apoptosis in human lung cancer cell lines.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, X.-H., Li, T., Fong, C.M., et al. Saponins from Chinese medicines as anticancer agents. Molecules 21(10), pii:E1326 (2016).

    2. Cai, J., Liu, M., Wang, Z., et al. Apoptosis induced by dioscin in Hela cells. Biol. Pharm. Bull. 25(2), 193-196 (2002).

    3. Lee, K.J., Oh, Y.C., Cho, W.K., et al. Antioxidant and anti-inflammatory activity determination of one hundred kinds of pure chemical compounds using offline and online screening HPLC assay. Evid. Based Complement. Alternat. Med. 165457 (2015).

    4. Zhou, Q., Song, W., and Xiao, W. Dioscin induces demethylation of DAPK-1 and RASSF-1α genes via the antioxidant capacity, resulting in apoptosis of bladder cancer T24 cells. EXCLI J. 16, 101-112 (2017).

    5. Hsieh, M.-J., Tsai, T.-L., Hsieh, Y.-S., et al. Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines. Arch. Toxicol. 87(11), 1927-1937 (2013).