A saponin with diverse biological activities
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Isomer(s)
22431Astragaloside I 11834Dioscin
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Isoastragaloside I

Item No. 40279

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,6α,16β,20R,24S)-3-[(2,4-di-O-acetyl-β-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl-β-D-glucopyranoside
CAS Number
84676-88-0
Molecular Formula
C45H72O16
Formula Weight
869.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleDMSO: Soluble
SMILES
C[C@]12[C@@]3([H])[C@@]4(CC[C@@]1([C@]([C@]5(C)O[C@H](C(C)(O)C)CC5)([H])[C@H](C2)O)C)[C@@]6([C@@](C(C)([C@H](CC6)O[C@H]7[C@@H]([C@H]([C@@H](CO7)OC(C)=O)O)OC(C)=O)C)([H])[C@H](C3)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)CO)C4
InChi Code
InChI=1S/C45H72O16/c1-21(47)56-26-19-55-38(34(31(26)51)57-22(2)48)60-28-11-13-45-20-44(45)15-14-41(7)35(43(9)12-10-29(61-43)40(5,6)54)23(49)17-42(41,8)27(44)16-24(36(45)39(28,3)4)58-37-33(53)32(52)30(50)25(18-46)59-37/h23-38,46,49-54H,10-20H2,1-9H3/t23-,24-,25+,26+,27-,28-,29-,30+,31-,32-,33+,34+,35-,36-,37+,38-,41+,42-,43+,44-,45+/m0/s1
InChi Key
HVPKALQHGQMJER-XOUPSZAESA-N
Origin
Plant/Astragalus membranaceus (Fisch.) Bunge
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    Isoastragaloside I is a saponin that has been found in A. membranaceus and has diverse biological activities.1,2,3 It inhibits LPS-induced production of nitric oxide (NO), TNF-α, and IL-1β, as well as inhibits NF-κB phosphorylation in BV-2 microglia when used at concentrations ranging from 25 to 100 µM.1 Isoastragaloside I (2-10 µg/ml) induces adiponectin production in 3T3-L1 adipocytes.2 It induces the expression of β-cell differentiation genes and increases mRNA levels of the endocrine progenitor marker Ngn3 and the β-cell markers insulin1 and insulin2 in mouse pancreatic ductal organoids (mPDOs).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, H., Huang, F., Wu, H., et al. Isoastragaloside I inhibits NF-κB activation and inflammatory responses in BV-2 microglial cells stimulated with lipopolysaccharide. Int. J. Mol. Med. 40(4), 1270-1276 (2017).

    2. Xu, A., Wang, H., Hoo, R.L., et al. Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice. Endocrinology 150(2), 625-633 (2009).

    3. Yu, W., Wang, Y., Jiang, D., et al. A saponin from astragalus promotes pancreatic ductal organoids differentiation into insulin-producing cells. Phytomedicine 102:154190, (2022).