A triterpenoid with diverse biological activities
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Isomer(s)
30620Polygalacic Acid
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Madecassic Acid

Item No. 11854

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2α,3β,4α,6β)-2,3,6,23-tetrahydroxy-urs-12-en-28-oic acid
CAS Number
18449-41-7
Synonyms
  • Brahmic Acid
  • NSC 88135
Molecular Formula
C30H48O6
Formula Weight
504.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mLDMF:PBS (pH 7.2) (1:9): 0.1 mg/mLDMSO: 5 mg/mLEthanol: 3 mg/mL
SMILES
OC[C@]1(C)[C@@H](O)[C@H](O)C[C@@]2(C)[C@@]1([H])[C@H](O)C[C@]3(C)[C@]2([H])CC=C4[C@@]3(C)CC[C@]5(C(O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5
InChi Code
InChI=1S/C30H48O6/c1-16-9-10-30(25(35)36)12-11-28(5)18(22(30)17(16)2)7-8-21-26(3)13-20(33)24(34)27(4,15-31)23(26)19(32)14-29(21,28)6/h7,16-17,19-24,31-34H,8-15H2,1-6H3,(H,35,36)/t16-,17+,19-,20-,21-,22+,23-,24+,26-,27+,28-,29-,30?/m1/s1
InChi Key
PRAUVHZJPXOEIF-QUKJEOBDSA-N
Origin
Plant/Centella asiatica
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    100 mg

    $40

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    250 mg

    $90

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    500 mg

    $129

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    1 g

    $197

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    Product Description

    Madecassic acid is a triterpenoid that has been found in C. asiatica and has diverse biological activities.1,2,3 It inhibits LPS-induced production of nitric oxide (NO), prostaglandin E2 (PGE2; Item No. 14010), TNF-α, IL-1β, and IL-6 in RAW 264.7 macrophages when used at a concentration of 150 µg/ml.1 Madecassic acid (0.05 and 0.1% in the diet) decreases plasma levels of fibrinogenin and triglycerides, as well as heart and kidney levels of reactive oxygen species (ROS), in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104).2 It decreases tumor growth in a CT26 murine colon cancer model in a dose-dependent manner.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Won, J.H., Shin, J.S., Park, H.J., et al. Anti-inflammatory effects of madecassic acid via the suppression of NF-κB pathway in LPS-induced RAW 264.7 macrophage cells. Planta Med. 76(3), 251-257 (2010).

    2. Hsu, Y.M., Hung, Y.c., Hu, L., et al. Anti-diabetic effects of madecassic acid and rotundic acid. Nutrients 7(12), 10065-10075 (2015).

    3. Zhang, H., Zhang, M., Tao, Y., et al. Madecassic acid inhibits the mouse colon cancer growth by inducing apoptosis and immunomodulation. J. BUON. 19(2), 372-376 (2014).