A diabetogenic agent which targets beta cells
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Product Categories

Product Type

Biochemicals

Research Area

Endocrinology & Metabolism
Metabolic Diseases
Diabetes

Streptozotocin

Item No. 13104

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose
CAS Number
18883-66-4
Synonyms
  • Estreptozocin
  • NSC 37917
  • NSC 85998
  • Streptozocin
  • STZ
  • U 9889
Molecular Formula
C8H15N3O7
Formula Weight
265.2
Purity
≥95% (mixture of isomers)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.01 M Sodium Citrate: 30 mg/mlDMF: 5 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
229 nm
SMILES
O[C@@H]([C@H](O)[C@H](O)CO)[C@H](C=O)NC(N(N=O)C)=O
InChi Code
InChI=1S/C8H15N3O7/c1-11(10-18)8(17)9-4(2-12)6(15)7(16)5(14)3-13/h2,4-7,13-16H,3H2,1H3,(H,9,17)/t4-,5+,6+,7+/m0/s1
InChi Key
AGRCPNMCOXLKFO-BDVNFPICSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

    $32

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    100 mg

    $54

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    500 mg

    $128

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    1 g

    $160

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    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Streptozotocin (STZ) is a glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals.1,2 It specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA.3,4 DNA damage induces activation of poly ADP-ribosylation, depletion of cellular NAD+ and ATP, and formation of superoxide radicals, leading to the destruction of beta cells.1 The effectiveness of STZ depends on the level of GLUT2 expression, which in turn may be influenced by age, sex, strain, or species.2,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Szkudelski, T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol. Res. 50(6), 537-546 (2001).

    2. Leiter, E.H. Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: Influence of inbred background, sex, and thymus. Proc. Natl. Acad. Sci. USA 79(2), 630-634 (1982).

    3. Melmed, R.N., Benitez, C.J., and Holt, S.J. Intermediate cells of the pancreas. III. Selective autophagy and destruction of β-granules in intermediate cells of the rat pancreas induced by alloxan and streptozotocin. J. Cell Sci. 13(1), 297-315 (1973).

    4. Bennett, R.A., and Pegg, A.E. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 41(7), 2786-2790 (1981).

    5. Kramer, J., Moeller, E.L., Hachey, A., et al. Differential expression of GLUT2 in pancreatic islets and kidneys of New and Old World nonhuman primates. Am. J. Physiol. Regul. Integr. Comp. Physiol. 296(3), R786-R793 (2009).

    Product Citations

    Alhowail, A., Aldawsari, M.F., and Aldubayan, M. Comparative analysis of pioglitazone and tirzepatide on body weight, glucose levels, neuroinflammation, and oxidative stress in diabetic rats. Drug Des. Devel. Ther. 31, 6605-6618 (2025).