FPS-ZM1

FPS-ZM1 is a high-affinity inhibitor of the receptor for advanced glycation end products (RAGE; K_i = 25 nM).¹ It blocks the binding of amyloid β (Aβ) protein to RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells.¹ FPS-ZM1 is functional in mice when administered intraperitoneally and penetrates the blood-brain barrier (BBB), inhibiting β-secretase activity, Aβ production, microglia activation, and neuroinflammation.^1,2 FPS-ZM1 is used to elucidate the role of RAGE-mediated signaling in diverse physiological processes in vivo, including cancer tumor growth, angiogenesis, and metastasis, as well as BBB damage, edema, and inflammation after intracerebral hemorrhage.^3,4

WARNING This product is not for human or veterinary use.

1. Deane, R., Singh, I., Sagare, A.P., et al. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J. Clin. Invest. 122(4), 1377-1392 (2012).

2. Hong, Y., Shen, C., Yin, Q., et al. Effects of RAGE-specific inhibitor FPS-ZM1 on amyloid-β metabolism and AGEs-induced inflammation and oxidative stress in rat hippocampus. Neurochem. Res. 41(5), 1192-1199 (2016).

3. Kwak, T., Drews-Elger, K., Ergonul, A., et al. Targeting of RAGE-ligand signaling impairs breast cancer cell invasion and metastasis. Oncogene 36(11), 1559-1572 (2016).

4. Yang, F., Wang, Z., Zhang, J.H., et al. Receptor for advanced glycation end-product antagonist reduces blood-brain barrier damage after intracerebral hemorrhage. Stroke 46(5), 1328-1336 (2015).