A 5-HT2B receptor antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

LY266097 (hydrochloride)

Item No. 11935

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(2-chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole, monohydrochloride
CAS Number
172895-39-5
Molecular Formula
C21H23ClN2O2 • HCl
Formula Weight
407.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: 30mg/mL
λmax
211, 228, 231, 242, 275 nm
SMILES
ClC1=C(OC)C(OC)=CC=C1CC(NCC2)C3=C2C4=CC(C)=CC=C4N3.Cl
InChi Code
InChI=1S/C21H23ClN2O2.ClH/c1-12-4-6-16-15(10-12)14-8-9-23-17(20(14)24-16)11-13-5-7-18(25-2)21(26-3)19(13)22;/h4-7,10,17,23-24H,8-9,11H2,1-3H3;1H
InChi Key
KPXKZZURYAXZQE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $36

    Add

    1 mg

    $55

    Add

    5 mg

    $153

    Add

    10 mg

    $236

    Add
    Product Description

    LY266097 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2B (Ki = 0.5 nM).1 It is selective for 5-HT2B over 5-HT2A and 5-HT2C receptors (Kis = 19.5 and 24.55 nM, respectively).2 LY266097 (100 nmol, intrathecal) reduces hind paw tactile allodynia induced by L5/L6 spinal nerve ligation in a rat model of neuropathic pain.3 It also reduces hyperlocomotion induced by cocaine in rats when administered at a dose of 0.63 mg/kg without reducing cocaine-induced dopamine outflow in the nucleus accumbens shell.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Auclair, A.L., Cathala, A., Sarrazin, F., et al. The central serotonin2B receptor: A new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity. J. Neurochem. 115(5), 1323-1332 (2010).

    2. Audia, J.E., Evrard, D.A., Murdoch, G.R., et al. Potent, selective tetrahydro-β-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus. J. Med. Chem. 39(14), 2773-2780 (1996).

    3. Pineda-Farias, J.B., Velázquez-Lagunas, I., Barragán-Iglesias, P., et al. 5-HT2B receptor antagonists reduce nerve injury-induced tactile allodynia and expression of 5-HT2B receptors. Drug Dev. Res. 76(1), 31-39 (2015).

    4. Devroye, C., Cathala, A., Di Marco, B., et al. Central serotonin2B receptor blockade inhibits cocaine-induced hyperlocomotion independently of changes of subcortical dopamine outflow. Neuropharmacology 97, 329-337 (2015).